Synthesis and Antiviral Activity Evaluation of Nitroporphyrins and Nitrocorroles as Potential Agents against Human Cytomegalovirus Infection.

6533b827fe1ef96bd1285de7

RESEARCH PRODUCT

Synthesis and Antiviral Activity Evaluation of Nitroporphyrins and Nitrocorroles as Potential Agents against Human Cytomegalovirus Infection.

Claude P. Gros Nicolas Desbois Franck Gallardo Eloise Demilly Anne-françoise Tilkin-mariamé Clément Michelin Bernard Mariamé

subject

Human cytomegalovirus Human health Infectious Diseases Chemistry medicine In vivo toxicity medicine.disease Virology

description

Different nitroporphyrinoid derivatives were synthesized and studied as potential agents against human Cytomegalovirus. Interestingly, two nitrocorroles display strong activity against human Cytomegalovirus with IC 50 < 0.5 μM. These compounds also possess antiproliferative activities without detected in vivo toxicity. Therefore, nitrocorroles appear for the first time as potential active compounds that can be applied in human health.

year	journal	country	edition	language
2015-06-02	ACS infectious diseases

10.1021/acsinfecdis.5b00020 https://pubmed.ncbi.nlm.nih.gov/27624883

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