Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear(1). Here the Metformin Genetics (MetGen) Consortium reports a three-stage genome-wide association study (GWAS), consisting of 13,123 participants of different ancestries. The C allele of rs8192675 in the intron of SLC2A2, which encodes the facilitated glucose transporter GLUT2, was associated with a 0.17% (P = 6.6 x 10(-14)) greater metformin-induced reduction in hemoglobin A1c (HbA1c) in 10,577 participants of European ancestry. rs8192675 was the top cis expression quantitative trait locus (cis-eQTL) for SLC2A2 in 1,226 human liver samples, suggesting a key role …

Effects of dissolved organic matter from a eutrophic lake on the freely dissolved concentrations of emerging organic contaminants

The authors studied the effects of dissolved organic matter (DOM) on the bioavailability of bisphenol A (BPA) and chloramphenicol by measuring the freely dissolved concentrations of the contaminants in solutions containing DOM that had been isolated from a mesocosm in a eutrophic lake. The abundance and aromaticity of the chromophoric DOM increased over the 25-d mesocosm experiment. The BPA freely dissolved concentration was 72.3% lower and the chloramphenicol freely dissolved concentration was 56.2% lower using DOM collected on day 25 than using DOM collected on day 1 of the mesocosm experiment. The freely dissolved concentrations negatively correlated with the ultraviolent absorption coef…

Automatic Segmentation of Pulmonary Lobes in Pulmonary CT Images using Atlas-based Unsupervised Learning Network

Pulmonary lobes segmentation of pulmonary CT images is important for assistant therapy and diagnosis of pulmonary disease in many clinical tasks. Recently supervised deep learning methods are applied widely in fast automatic medical image segmentation including pulmonary lobes segmentation of pulmonary CT images. However, they require plenty of ground truth due to their supervised learning scheme, which are always difficult to realize in practice. To address this issue, in this study we extend an existed unsupervised learning network with an extra pulmonary mask constraint to develop a deformable pulmonary lobes atlas and apply it for fast automatic segmentation of pulmonary lobes in pulmon…

Subduction‐Induced Back‐Arc Extension Versus Far‐Field Stretching: Contrasting Modes for Continental Marginal Break‐Up

3D Geodynamic Models for HP‐UHP Rock Exhumation in Opposite‐Dip Double Subduction‐Collision Systems