0000000000294425

AUTHOR

David Y.w. Lee

showing 5 related works from this author

Traditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis.

2020

Abstract Background Throughout the 5000-year history of China, more than 300 epidemics were recorded. Traditional Chinese herbal medicine (TCM) has been used effectively to combat each of these epidemics’ infections, and saved many lives. To date, there are hundreds of herbal TCM formulae developed for the purpose of prevention and treatment during epidemic infections. When COVID-19 ravaged the Wuhan district in China in early January 2020, without a deep understanding about the nature of COVID-19, patients admitted to the TCM Hospital in Wuhan were immediately treated with TCM and reported later with >90% efficacy. Approach We conducted conduct a systematic survey of various TCM herbal pre…

PTGS2 Prostaglandin-endoperoxide synthase 2BattleAIV avian influenza virusCoV coronavirusPharmaceutical ScienceiNOS nitric oxide synthaseViral infection0302 clinical medicinePA patchouli alcoholSARS Severe Acute Respiratory SyndromeSMD Sheganmahuang decoctionDrug DiscoveryPandemicIL InterleukinMedicine Chinese TraditionalALI acute lung injuriesmedia_commonCOVID-19 coronavirus disease 2019MXSG Ma xing shi gan decoction0303 health sciencesTNF tumor necrosis factorClinical Trials as TopicCCL2 CC chemokine ligand 2FM1 FM1 coronavirusICU intensive care unitc-AMP cyclic adenosine phosphateHIV human immunodeficiency virus030220 oncology & carcinogenesisCOX-2 cyclooxygenase-2Molecular MedicineHerbal preparationsMedicinal herbsAbbreviations: ACE2 angiotensin-converting enzyme IITCM traditional Chinese medicineHSV-1 herpes simplex virus 1CASP3 caspase 3medicine.medical_specialtyChinaCoronavirus disease 2019 (COVID-19)Systematic surveymedia_common.quotation_subjectJEV Japanese encephalitis virusNF-κB nuclear factor kappa B cellsAntiviral AgentsArticleWHO World Health Organization03 medical and health sciencesIEC-6 rat intestinal epithelial cell line 6SOD superoxide dismutaseCDC Center for Disease Control and PreventionmedicineAVP arginine vasopressinPGE2 prostaglandin E2HumansIntensive care medicineLH Lianhuaqingwen capsule030304 developmental biologyPharmacologyMedicinal herbMDA malondialdehydeGCGJ Gancao ganjiang decoctionNO nitric oxidePlants Medicinalbusiness.industrySARS-CoV-2COVID-19CXCL C-X-C- motif chemokineMDCK Madin-Darby Canine Kidney cellsTLR-4 Toll-like receptor-4COVID-19 Drug TreatmentComplementary and alternative medicineViral infectionLPS lipopolysaccharidesRSV respiratory syncytial virusQFPD Qingfeipaidu decoctionbusinessLung congestionECMO extracorporeal membrane oxygenationMAPK mitogen-activated protein kinasePhytotherapyDrugs Chinese HerbalPhytomedicine : international journal of phytotherapy and phytopharmacology
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Can eastern wisdom resolve western epidemics? Traditional Chinese medicine therapies and the opioid crisis.

2020

The widespread use of opioids to treat chronic pain led to a nation-wide crisis in the United States. Tens of thousands of deaths annually occur mainly due to respiratory depression, the most dangerous side effect of opioids. Non-opioid drugs and non-pharmacological treatments without addictive potential are urgently required. Traditional Chinese medicine (TCM) is based on a completely different medical theory than academic Western medicine. The scientific basis of acupuncture and herbal treatments as main TCM practices has been considerably improved during the past two decades, and large meta-analyses with thousands of patients provide evidence for their efficacy. Furthermore, opinion lead…

medicine.medical_specialtyModalitiesbusiness.industryChronic painAcupuncture TherapyGeneral MedicineTraditional Chinese medicinemedicine.diseaseUnited StatesScientific evidenceClinical trialAnalgesics OpioidOpioidAcupunctureMedicineHumansMedicine Chinese TraditionalOpioid EpidemicbusinessIntensive care medicineEpidemicsDepression (differential diagnoses)medicine.drugDrugs Chinese HerbalJournal of integrative medicine
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Role of Levo-tetrahydropalmatine and its metabolites for management of chronic pain and opioid use disorders.

2021

Abstract Background Opioids have been prescribed to reduce suffering from pain and to enhance quality of life. Due to the addictive potential and the lack of other effective alternatives to treat severe acute and chronic pains, opioids remain a serious public health issue. While, opioids directly influence the drug-seeking behavior, tolerance and withdrawal processes, through neuroadaptation, the brain's endogenous opioid system also adapts in the presence of chronic pain and could contribute to the difficulty of treatment. Despite the seemingly obvious interaction between the presence of pain and opioid-abuse, little is known about the underlying mechanisms in the brain. Purpose To review …

Drugmedia_common.quotation_subjectAnalgesicBerberine AlkaloidsPharmaceutical ScienceBioinformaticsPartial agonist03 medical and health sciences0302 clinical medicineDrug DiscoverymedicineHumans030304 developmental biologyEndogenous opioidmedia_commonPharmacology0303 health sciencesbusiness.industryAddictionChronic painOpioid use disordermedicine.diseaseOpioid-Related DisordersClinical trialAnalgesics OpioidComplementary and alternative medicine030220 oncology & carcinogenesisQuality of LifeMolecular MedicineChronic PainbusinessPhytomedicine : international journal of phytotherapy and phytopharmacology
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Health(care) in the Crisis: Reflections in Science and Society on Opioid Addiction

2021

Opioid abuse and misuse have led to an epidemic which is currently spreading worldwide. Since the number of opioid overdoses is still increasing, it is becoming obvious that current rather unsystematic approaches to tackle this health problem are not effective. This review suggests that fighting the opioid epidemic requires a structured public health approach. Therefore, it is important to consider not only scientific and biomedical perspectives, but societal implications and the lived experience of groups at risk as well. Hence, this review evaluates the risk factors associated with opioid overdoses and investigates the rates of chronic opioid misuse, particularly in the context of chronic…

medicine.medical_specialtypatient narrativesHealth Toxicology and Mutagenesismedia_common.quotation_subjectlcsh:MedicineContext (language use)ReviewOxyContinopioid abuse03 medical and health sciences0302 clinical medicineHealth caremedicineHumansSocial inequality030212 general & internal medicineOpioid EpidemicPsychiatrymedia_commonbusiness.industryPublic healthAddictionlcsh:RPublic Health Environmental and Occupational HealthOpioid-Related DisordersChronic painmedicine.diseaseOpioid-Related DisordersAnalgesics OpioidBehavior AddictiveOpioidSocioeconomic Factorsbusinesschronic pain030217 neurology & neurosurgerymedicine.drugInternational Journal of Environmental Research and Public Health
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Combining the wisdoms of traditional medicine with cutting-edge science and technology at the forefront of medical sciences

2019

Abstract Background A central topic is to bring traditional medicine to a new horizon by integrating the latest advances in genomic, metabolomic, and system biological approaches, in order to re-examine the wisdom and knowledge of traditional Chinese medicine (TCM) and other traditional medicines. Purpose A new consortium has been formed at a conference of the Harvard Medical School, Boston, on October 29–30, 2018. The main goal was to build a collaborative platform for the scientific investigation of traditional medicine with cutting edge sciences and technologies at the forefront of biomedicine. Results Traditional medicines are largely experience-based, but the scientific basis is largel…

Pharmacology0303 health sciencesTraditional medicinebusiness.industryMedical schoolPharmaceutical ScienceOrgan functionTraditional Chinese medicine03 medical and health sciences0302 clinical medicineComplementary and alternative medicineDrug development030220 oncology & carcinogenesisDrug DiscoveryAcupunctureMolecular MedicineMedicinal herbsIntegrative medicinebusinessBiomedicine030304 developmental biologyPhytomedicine
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