0000000000294569
AUTHOR
Maren Person
Sex-specific signatures of intrinsic hippocampal networks and regional integrity underlying cognitive status in multiple sclerosis
Abstract The hippocampus is an anatomically compartmentalized structure embedded in highly wired networks that are essential for cognitive functions. The hippocampal vulnerability has been postulated in acute and chronic neuroinflammation in multiple sclerosis, while the patterns of occurring inflammation, neurodegeneration or compensation have not yet been described. Besides focal damage to hippocampal tissue, network disruption is an important contributor to cognitive decline in multiple sclerosis patients. We postulate sex-specific trajectories in hippocampal network reorganization and regional integrity and address their relationship to markers of neuroinflammation, cognitive/memory per…
Translational Research in Neuroimmunology: Cognition
Cognitive impairment affects up to 70% of patients with multiple sclerosis (MS). It may already be present in the early stages of disease and impedes with a patient’s ability to maintain employment, take part in activities of daily life, and fully participate in society. Similar to the clinical heterogeneity of MS, there is great variability in cognitive symptoms among patients. Given the impact of such deficits on everyday functioning, an increasing interest in diagnosis and treatment of cognitive impairment has arisen. This chapter aims to present an overview of those cognitive domains most commonly affected in MS, common approaches to assess the respective cognitive functions as well as …