0000000000294608

AUTHOR

Rahul Gaurav

0000-0001-9983-5873

showing 2 related works from this author

Automated classification of neurodegenerative parkinsonian syndromes using multimodal magnetic resonance imaging in a clinical setting

2020

ABSTRACTBackgroundSeveral studies have shown that machine learning algorithms using MRI data can accurately discriminate parkinsonian syndromes. Validation under clinical conditions is missing.ObjectivesTo evaluate the accuracy for the categorization of parkinsonian syndromes of a machine learning algorithm trained with a research cohort and tested on an independent clinical replication cohort.Methods361 subjects, including 94 healthy controls, 139 patients with PD, 60 with PSP with Richardson’s syndrome, 41 with MSA of the parkinsonian variant (MSA-P) and 27 with MSA of the cerebellar variant (MSA-P), were recruited. They were divided into a training cohort (n=179) scanned in a research en…

medicine.medical_specialtymedicine.diagnostic_testbusiness.industryParkinsonismMagnetic resonance imagingmedicine.diseaseTraining cohortnervous system diseases030218 nuclear medicine & medical imagingParkinsonian syndromes03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationstomatognathic systemnervous systemCategorizationmental disordersReplication (statistics)Research environmentCohortmedicinebusiness030217 neurology & neurosurgery
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Automated Categorization of Parkinsonian Syndromes Using Magnetic Resonance Imaging in a Clinical Setting

2020

Background Machine learning algorithms using magnetic resonance imaging (MRI) data can accurately discriminate parkinsonian syndromes. Validation in patients recruited in routine clinical practice is missing. Objective The aim of this study was to assess the accuracy of a machine learning algorithm trained on a research cohort and tested on an independent clinical replication cohort for the categorization of parkinsonian syndromes. Methods Three hundred twenty-two subjects, including 94 healthy control subjects, 119 patients with Parkinson's disease (PD), 51 patients with progressive supranuclear palsy (PSP) with Richardson's syndrome, 35 with multiple system atrophy (MSA) of the parkinsoni…

0301 basic medicinemedicine.medical_specialtyParkinson's diseaseParkinson's diseasemultiple system atrophyProgressive supranuclear palsyDiagnosis Differential03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationParkinsonian DisordersmedicineHumansmultimodal magnetic resonance imagingReceiver operating characteristicmedicine.diagnostic_testbusiness.industryParkinsonismMagnetic resonance imagingprogressive supranuclear palsymedicine.diseaseMagnetic Resonance Imaging3. Good healthnervous system diseasesmachine learning algorithm030104 developmental biologyDiffusion Tensor ImagingNeurologyCategorizationnervous systemCohort[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Neurology (clinical)Supranuclear Palsy Progressivebusiness030217 neurology & neurosurgeryDiffusion MRI
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