0000000000297087
AUTHOR
Jean M. Petit
PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes
Context: Recently, it has been shown that an allele in the adiponutrin (PNPLA3) gene was strongly associated with increased liver fat content (LFC) and liver fibrosis independent of visceral adiposity and insulin resistance. Objective: In this study, we set out to determine whether the PNPLA3 rs738409 polymorphism was associated with liver fibrosis in unselected patients with type 2 diabetes. Design, setting and participants: Two hundred and thirty-four patients with type 2 diabetes were included in this study. Main outcome measures: LFC was evaluated using 1H-MR spectroscopy; fibrosis was measured using the non-invasive FibroTest®. Results: Advanced liver fibrosis (stage F2 or above) was o…
OSSOS XVIII: Constraining migration models with the 2:1 resonance using the Outer Solar System Origins Survey
Resonant dynamics plays a significant role in the past evolution and current state of our outer Solar System. The population ratios and spatial distribution of Neptune's resonant populations are direct clues to understanding the history of our planetary system. The orbital structure of the objects in Neptune's 2:1 mean-motion resonance (\emph{twotinos}) has the potential to be a tracer of planetary migration processes. Different migration processes produce distinct architectures, recognizable by well-characterized surveys. However, previous characterized surveys only discovered a few twotinos, making it impossible to model the intrinsic twotino population. With a well-designed cadence and n…
OSSOS. IX. Two objects in Neptune's 9:1 resonance: implications for resonance sticking in the scattering population
We discuss the detection in the Outer Solar System Origins Survey (OSSOS) of two objects in Neptune's distant 9:1 mean motion resonance at semimajor axis $a\approx~130$~au. Both objects are securely resonant on 10~Myr timescales, with one securely in the 9:1 resonance's leading asymmetric libration island and the other in either the symmetric or trailing asymmetric island. These objects are the largest semimajor axis objects with secure resonant classifications, and their detection in a carefully characterized survey allows for the first robust resonance population estimate beyond 100~au. The detection of these objects implies a 9:1 resonance population of $1.1\times10^4$ objects with $H_r&…