0000000000298102
AUTHOR
Franz-peter Montforts
Radiolabelling and preliminary evaluation of 68Ga-tetrapyrrole derivatives as potential tracers for PET
article i nfo Tetrapyrroles are multisided natural products which are of relevance in clinical medicine. Owing to their specific accumulation in tumour tissue, porphyrins, metalloporphyrins and chlorins have been used as in photodynamic therapy and optical imaging. Moreover, their specific uptake into inflammatory atheromatous plaques via LDL endocytosis has been reported. The present study is concerned with the synthesis of 68 Ga labelled porphyrin derivatives and an in vitro assessment of the utility of radiotracers in positron emission tomography. A set of five porphyrin derivatives were labelled using 68 Ga from a commercially obtained radionuclide generator. Dedicated post-processing o…
Pyrolysis/gas chromatography/mass spectrometry analysis of 5,10,15,20-tetraphenyl-21H,23H-porphyrin and some of its derivatives
A coupled on-line pyrolysis/gas chromatography/mass spectrometry technique (Py/GC/MS) was applied to identify products of pyrolysis of 5,10,15,20-tetraphenyl-21H,23H-porphyrin (1a) and its methyl and hydroxyl substituted derivatives (1b and 1c). The mass spectra of some important pyrolitic products are presented and mass fragmentation of this type compounds is discussed. From the investigation it can be concluded that the direction of the main thermal (pyrolytic) reactions is similar for all compounds studied: namely breaking of the porphyrin macrocycle followed by splitting of molecule fragments containing one, two or three pyrrole and/or benzene rings. The products of pyrolysis can be sim…