0000000000298558
AUTHOR
Paula Ramirez
showing 5 related works from this author
Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study
2021
Background: To date, 750 000 patients with COVID-19 worldwide have required mechanical ventilation and thus are at high risk of acute brain dysfunction (coma and delirium). We aimed to investigate the prevalence of delirium and coma, and risk factors for delirium in critically ill patients with COVID-19, to aid the development of strategies to mitigate delirium and associated sequelae. Methods: This multicentre cohort study included 69 adult intensive care units (ICUs), across 14 countries. We included all patients (aged ≥18 years) admitted to participating ICUs with severe acute respiratory syndrome coronavirus 2 infection before April 28, 2020. Patients who were moribund or had life-suppo…
In vitro study of antimicrobial activity on Klebsiella Pneumoniae biofilms in endotracheal tubes
2019
Effective treatment approaches for biofilms in endotracheal tubes (ETTs) are lacking. In this study, we evaluated the in vitro effects of five antimicrobials against biofilms formed by Klebsiella pneumoniae in ETTs. K. pneumoniae was added to minimal mucin medium prior to inoculation in microtiter plates containing ETT fragments. Biofilm susceptibility was assessed by crystal violet staining. At 24 h, the antimicrobials significantly reduced biofilm formation. At 48 h, all of the antimicrobial agents exhibited significant reductions in biofilm formation, even at concentrations above the minimum inhibitory concentration (MIC). Tigecycline and fosfomycin showed the greatest inhibition capacit…
Acceptance and validity of the methods used to implement a competency based medical education programme in an Intensive Care Department of a teaching…
2021
Abstract Objectives 1. To determine the satisfaction of tutors and residents with a specific methodology used to implement CoBaTrICE. 2. To determine the reliability and validity of the global rating scales designed ad hoc to assess the performance of the residents for training purposes. Design Prospective cohort study. Participants All the residents and tutors of the ICU Department of the Hospital Universitario y Politecnico la Fe de Valencia. Intervention CoBaTrICE implementation started in March 2016, it was based on: (1) Training the tutors in feedback techniques; (2) Performing multiple objective and structured work based assessments to achieve the competences of the program; and (3) T…
Time-kill assays of amphotericin B plus anidulafungin against Candida tropicalis biofilms formed on two different biomaterials.
2017
Purpose: To determine the fungicidal activity by time-killing assays of amphotericin B (AMB) combined with anidulafungin (ANF) against biofilms of 2 clinical isolates of Candida tropicalis and the reference strain ATCC® 750, developed on polytetrafluoroethylene (PTFE) and titanium, using the CDC Biofilm Reactor (CBR) as an in vitro model. Methods: Biofilms were developed for 24 hours on the disk surfaces and then exposed to AMB (40 mg/L), ANF (8 mg/L), alone and combined. At predetermined time points after drug exposure, biofilms were removed from the disk surface by vortexing-sonication to quantify viable biofilm cells. Results: Drug activity was dependent on strain and time. After exposur…
Análisis de la aceptación y validez de los métodos utilizados para la implementación de un programa de formación basado en competencias en un servici…
2021
Resumen Objetivos 1) Determinar la satisfaccion de tutores y residentes con la metodologia utilizada para la implementacion de CoBaTrICE, y 2) determinar la validez y la fiabilidad de las escalas de valoracion global disenados ad hoc para analizar el desempeno de los residentes con fines formativos. Diseno Estudio prospectivo de cohortes. Participantes Todos los residentes y tutores del Servicio de Medicina Intensiva del Hospital Universitario y Politecnico La Fe de Valencia. Intervencion En marzo del 2016 se inicio la implementacion de CoBaTrICE sustentada en: 1) formacion de los tutores en tecnicas de retroalimentacion; 2) realizacion por los residentes de multiples ejercicios reales de e…