A European multicentre photopatch test study

The two most common agent groups currently responsible for photoallergic contact dermatitis (PACD) are organic ultraviolet (UV) absorbers in sunscreens and topical nonsteroidal anti-inflammatory drugs (NSAIDs). However, availability of information on the photoallergenic potential of these agents is scarce.To obtain current information on the frequency of PACD to 19 organic UV absorbers and five topical NSAIDs, including newer agents, in common usage in Europe.A prospective, multicentre photopatch test study was conducted with 1031 patients attending for investigation of suspected PACD in 30 centres across 12 European countries.A total of 346 PACD reactions in 200 (19·4%) subjects occurred. …

Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation

Dendritic cells (DCs) have been implicated in the pathogenesis of psoriasis but the roles for specific DC subsets are not well defined. Here we show that DCs are required for psoriasis-like changes in mouse skin induced by the local injection of IL-23. However, Flt3L-dependent DCs and resident Langerhans cells are dispensable for the inflammation. In epidermis and dermis, the critical DCs are TNF-producing and IL-1β-producing monocyte-derived DCs, including a population of inflammatory Langerhans cells. Depleting Ly6Chi blood monocytes reduces DC accumulation and the skin changes induced either by injecting IL-23 or by application of the TLR7 agonist imiquimod. Moreover, we find that IL-23-…

The reaction of enones with electrophiles

Violation of the equivalence principle from light scalar dark matter

In this paper, we study the local observational consequences of a violation of the Einstein Equivalence Principle induced by models of light scalar Dark Matter (DM). We focus on two different models where the scalar field couples linearly or quadratically to the standard model of matter fields. For both these cases, we derive the solutions of the scalar field. We also derive from first principles the expressions for two types of observables: (i) the local comparison of two atomic sensors that are differently sensitive to the constants of Nature and (ii) the local differential acceleration between two test-masses with different compositions. For the linear coupling, we recover that the signa…