0000000000300042

AUTHOR

M. A. Steiner

showing 2 related works from this author

Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice.

2007

Dysregulation of the endocannabinoid system is known to interfere with emotional processing of stressful events. Here, we studied the role of cannabinoid receptor type 1 (CB1) signaling in stress-coping behaviors using the forced swim test (FST) with repeated exposures. We compared effects of genetic inactivation with pharmacological blockade of CB1 receptors both in male and female mice. In addition, we investigated potential interactions of the endocannabinoid system with monoaminergic and neurotrophin systems of the brain. Naive CB1 receptor-deficient mice (CB1-/-) showed increased passive stress-coping behaviors as compared to wild-type littermates (CB1+/+) in the FST, independent of se…

Malemedicine.medical_specialtyCannabinoid receptormedicine.medical_treatmentBiologyPharmacologyHippocampusMicePiperidinesReceptor Cannabinoid CB1Internal medicineCannabinoid receptor type 1MonoaminergicAdaptation PsychologicalGeneticsmedicineAnimalsBiogenic MonoaminesRNA MessengerReceptorMonoamine OxidaseSwimmingPharmacologyBrain-derived neurotrophic factormusculoskeletal neural and ocular physiologyBrain-Derived Neurotrophic FactorDesipraminefood and beveragesEndocannabinoid systemMice Inbred C57BLMonoamine neurotransmitterEndocrinologynervous systemVesicular Glutamate Transport Protein 1Molecular MedicinePyrazoleslipids (amino acids peptides and proteins)FemaleCannabinoidRimonabantpsychological phenomena and processesStress PsychologicalSignal TransductionThe pharmacogenomics journal
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Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice.

2007

Hypothalamic-pituitary-adrenocortical (HPA) axis hyperactivity is associated with major depressive disorders, and treatment with classical antidepressants ameliorates not only psychopathological symptoms, but also the dysregulation of the HPA axis. Here, we further elucidated the role of impaired cannabinoid type 1 receptor (CB1) signaling for neuroendocrine and behavioral stress coping in the mouse forced swim test (FST). We demonstrate that the genetic inactivation of CB1 is accompanied by increased plasma corticosterone levels both under basal conditions and at different time points following exposure to the FST. The latter effect could be mimicked in C57BL/6N mice by acute, subchronic, …

Malemedicine.medical_specialtyCannabinoid receptorTime FactorsEndocrinology Diabetes and Metabolismmedicine.medical_treatmentAntidepressive Agents TricyclicStatistics NonparametricArticlechemistry.chemical_compoundMiceEndocrinologyRimonabantPiperidinesReceptor Cannabinoid CB1CorticosteroneDesipramineInternal medicineCannabinoid receptor type 1Adaptation PsychologicalmedicineAnimalsBiological PsychiatrySwimmingMice KnockoutAnalysis of VarianceEndocrine and Autonomic SystemsDepressionDesipramineMice Inbred C57BLPsychiatry and Mental healthDisease Models AnimalEndocrinologychemistrynervous systemPyrazoleslipids (amino acids peptides and proteins)FemaleCannabinoidRimonabantPsychologyCorticosteronehuman activitiesGlucocorticoidStress Psychologicalmedicine.drugBehavioural despair testSignal TransductionPsychoneuroendocrinology
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