Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborat…

Tin resonance-ionization schemes for atomic- And nuclear-structure studies

This paper presents high-precision spectroscopic measurements of atomic tin using five different resonance-ionization schemes performed with the collinear resonance-ionization spectroscopy technique. Isotope shifts were measured for the stable tin isotopes from the $5{s}^{2}5{p}^{2}\phantom{\rule{0.28em}{0ex}}^{3}{P}_{0,1,2}$ and ${}^{1}{S}_{0}$ to the $5{s}^{2}5p6s\phantom{\rule{0.28em}{0ex}}^{1}{P}_{1},^{3}{P}_{1,2}$ and $5{s}^{2}5p7s{\phantom{\rule{0.28em}{0ex}}}^{1}{P}_{1}$ atomic levels. The magnetic dipole hyperfine constants ${A}_{\mathrm{hf}}$ have been extracted for six atomic levels with electron angular momentum $Jg0$ from the hyperfine structures of nuclear spin $I=1/2$ tin isot…

Electron and photon performance measurements with the ATLAS detector using the 2015-2017 LHC proton-proton collision data

This paper describes the reconstruction of electrons and photons with the ATLAS detector, employed for measurements and searches exploiting the complete LHC Run 2 dataset. An improved energy clustering algorithm is introduced, and its implications for the measurement and identification of prompt electrons and photons are discussed in detail. Corrections and calibrations that affect performance, including energy calibration, identification and isolation efficiencies, and the measurement of the charge of reconstructed electron candidates are determined using up to 81 fb−1 of proton-proton collision data collected at √s=13 TeV between 2015 and 2017.

Evidence for $\eta_{c} \rightarrow \gamma\gamma$ and Measurement of $J/\psi\rightarrow 3\gamma$

The decay of $J/\psi$ to three photons is studied using $\psi(3686)\to\pi^+\pi^-J/\psi$ in a sample of $1.0641\times10^8$ $\psi(3686)$ events collected with the BESIII detector. Evidence of the direct decay of $\eta_c$ to two photons, $\eta_c\to\gamma\gamma$, is reported, and the product branching fraction is determined to be $\mathcal{B}(J/\psi\to\gamma\eta_c,\eta_c\to \gamma\gamma)=(4.5\pm1.2\pm0.6)\times10^{-6}$, where the first error is statistical and the second is systematic. The branching fraction for $J/\psi\to3\gamma$ is measured to be $(11.3\pm1.8\pm2.0)\times 10^{-6}$ with improved precision.

Performance of the upgraded PreProcessor of the ATLAS Level-1 Calorimeter Trigger

The PreProcessor of the ATLAS Level-1 Calorimeter Trigger prepares the analogue trigger signals sent from the ATLAS calorimeters by digitising, synchronising, and calibrating them to reconstruct transverse energy deposits, which are then used in further processing to identify event features. During the first long shutdown of the LHC from 2013 to 2014, the central components of the PreProcessor, the Multichip Modules, were replaced by upgraded versions that feature modern ADC and FPGA technology to ensure optimal performance in the high pile-up environment of LHC Run 2. This paper describes the features of the newMultichip Modules along with the improvements to the signal processing achieved.

Association Between Tumor Egfr and Kras Mutation Status and Clinical Outcomes in Nsclc Patients Randomized to Sorafenib Plus Best Supportive Care (BSC) or Bsc Alone: Subanalysis of the Phase III Mission Trial

ABSTRACT Background Tumor EGFR and KRas mutations are both predictive and prognostic biomarkers in patients with advanced NSCLC. We analyzed the correlation between these biomarkers and treatment outcomes in a phase III trial of 3rd/4th line sorafenib in patients with NSCLC. Methods The global, randomized, placebo-controlled MISSION trial enrolled 703 patients with advanced relapsed/refractory NSCLC of predominantly non-squamous histology. The primary study endpoint was overall survival (OS). EGFR and KRas mutations were analyzed in archival tumor samples and in circulating tumor DNA isolated from plasma. Results Tumor and/or plasma mutation data were available from 347 patients (49%). EGFR…

Prolonged breastfeeding is associated with greater bone size and bone strength

Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.

Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the role of CASP8 in breast cancer susceptibility, we carried out dense genotyping of this region in the Breast Cancer Association Consortium (BCAC). Single-nucleotide polymorphisms (SNPs) spanning a 1 Mb region around CASP8 were genotyped in 46 450 breast cancer cases and 42 600 controls of European origin from 41 studies participating in the BCAC as part of a custom genotyping array experiment (iCOGS). Missing genotypes and SNPs were imputed and, after quality exclusions, 501 typed and 1232 imputed SNPs were included in logistic regressionmodels adjusting for stud…

Surgeons' fear of getting infected by COVID19: A global survey

During the last three months, COVID- 19 pandemic had led to a serious backlog of operations globally, and plans for restarting operation are imperative. Recommendations for surgical activities were studied, aiming to protect the surgical staff from being infected. In the meantime, it is also important to give attention to the surgeon’s personal feeling during work. We conducted a survey to investigate global surgi- cal practices during the COVID-19 pandemic, and the surgeon’s personal feeling was also investigated in the sur- vey. In this special letter, we performed multivariate analysis to explore factors that associated with surgeon’s fear of getting infected by COVID-19.

RANDOMIZED PHASE II STUDY OF FIRST-LINE EVEROLIMUS (EVE) + BEVACIZUMAB (BEV) VERSUS INTERFERON ALFA-2A (IFN) + BEV IN PATIENTS (PTS) WITH METASTATIC RENAL CELL CARCINOMA (MRCC): RECORD-2

ABSTRACT Background Study results demonstrated that IFN augments BEV activity and improves median PFS in pts with mRCC. Thus, combination BEV + IFN is a standard first-line treatment option for mRCC. Combining BEV with the mTOR inhibitor EVE may be an efficacious and well-tolerated treatment option. The open-label, phase II RECORD-2 trial compared first-line EVE + BEV and IFN + BEV in mRCC. Patients and methods: Therapy-naive pts with clear cell mRCC and prior nephrectomy were randomized 1:1 to BEV 10 mg/kg IV every 2 weeks with either EVE 10 mg oral daily or IFN (9 MIU SC 3 times/week, if tolerated). Tumour assessments were every 12 weeks. Primary objective was treatment effect on progress…

Observation and Measurement of Forward Proton Scattering in Association with Lepton Pairs Produced via the Photon Fusion Mechanism at ATLAS

The observation of forward proton scattering in association with lepton pairs (eþe− þ p or μþμ− þ p) produced via photon fusion is presented. The scattered proton is detected by the ATLAS Forward Proton spectrometer, while the leptons are reconstructed by the central ATLAS detector. Proton-proton collision data recorded in 2017 at a center-of-mass energy of ffiffiffi s p ¼ 13 TeV are analyzed, corresponding to an integrated luminosity of 14.6 fb−1. A total of 57 (123) candidates in the ee þ p (μμ þ p) final state are selected, allowing the background-only hypothesis to be rejected with a significance exceeding 5 standard deviations in each channel. Proton-tagging techniques are introduced f…

African volcanic emissions influencing atmospheric aerosols over the Amazon rain forest

Long-range transport (LRT) plays an important role in the Amazon rain forest by bringing in different primary and secondary aerosol particles from distant sources. The atmospheric oxidation of dimethyl sulfide (DMS), emitted from marine plankton, is considered an important sulfate source over the Amazon rain forest, with a lesser contribution from terrestrial soil and vegetation sulfur emissions. Volcanic sulfur emissions from Africa could be a source of particulate sulfate to the Amazonian atmosphere upon transatlantic transport but no observations have been published. By using satellite observations, together with ground‑based and airborne aerosol particle observations, this paper provide…

Search for $\eta$ and $\eta'$ Invisible Decays in $J/\psi\to\phi\eta$ and $\phi\eta'$

Using a sample of $(225.3\pm 2.8)\times 10^{6}$ $J/\psi$ decays collected with the BESIII detector at BEPCII, searches for invisible decays of $\eta$ and $\eta^\prime$ in $J/\psi\to\phi\eta$ and $\phi\eta^\prime$ are performed. Decays of $\phi \to K^{+}K^{-}$ are used to tag the $\eta$ and $\eta^\prime$ decays. No signals above background are found for the invisible decays, and upper limits at the 90% confidence level are determined to be $2.58\times10^{-4}$ for the ratio $\frac{\mathcal{B}(\eta\to\rm{invisible})}{\mathcal{B}(\eta\to\gamma\gamma)}$ and $2.39\times10^{-2}$ for $\frac{\mathcal{B}(\eta^\prime\to\rm{invisible})}{\mathcal{B}(\eta^\prime \to\gamma\gamma)}$.

The DArk Matter Particle Explorer mission

The DArk Matter Particle Explorer (DAMPE), one of the four scientific space science missions within the framework of the Strategic Pioneer Program on Space Science of the Chinese Academy of Sciences, is a general purpose high energy cosmic-ray and gamma-ray observatory, which was successfully launched on December 17th, 2015 from the Jiuquan Satellite Launch Center. The DAMPE scientific objectives include the study of galactic cosmic rays up to $\sim 10$ TeV and hundreds of TeV for electrons/gammas and nuclei respectively, and the search for dark matter signatures in their spectra. In this paper we illustrate the layout of the DAMPE instrument, and discuss the results of beam tests and calib…

Measurement of photon?jet transverse momentum correlations in 5.02 TeV Pb + Pb and pp collisions with ATLAS

Jets created in association with a photon can be used as a calibrated probe to study energy loss in the medium created in nuclear collisions. Measurements of the transverse momentum balance between isolated photons and inclusive jets are presented using integrated luminosities of 0.49 nb−1 of Pb + Pb collision data at TeV and 25 pb−1 of pp collision data at TeV recorded with the ATLAS detector at the LHC. Photons with transverse momentum GeV and are paired with all jets in the event that have GeV and pseudorapidity . The transverse momentum balance given by the jet-to-photon ratio, , is measured for pairs with azimuthal opening angle . Distributions of the per-photon jet yield as a function…

Two-photon widths of the $\chi_{c0, 2}$ states and helicity analysis for $\chi_{c2}\ar\gamma\gamma$}

Based on a data sample of 106 M $\psi^{\prime}$ events collected with the BESIII detector, the decays $\psi^{\prime}\ar\gamma\chi_{c0, 2}$,$\chi_{c0, 2}\ar\gamma\gamma$ are studied to determine the two-photon widths of the $\chi_{c0, 2}$ states. The two-photon decay branching fractions are determined to be ${\cal B}(\chi_{c0}\ar\gamma\gamma) = (2.24\pm 0.19\pm 0.12\pm 0.08)\times 10^{-4}$ and ${\cal B}(\chi_{c2}\ar\gamma\gamma) = (3.21\pm 0.18\pm 0.17\pm 0.13)\times 10^{-4}$. From these, the two-photon widths are determined to be $\Gamma_{\gamma \gamma}(\chi_{c0}) = (2.33\pm0.20\pm0.13\pm0.17)$ keV, $\Gamma_{\gamma \gamma}(\chi_{c2}) = (0.63\pm0.04\pm0.04\pm0.04)$ keV, and $\cal R$ $=\Gamma…

Black and brown carbon over central Amazonia: long-term aerosol measurements at the ATTO site

The Amazon rainforest is a sensitive ecosystem experiencing the combined pressures of progressing deforestation and climate change. Its atmospheric conditions oscillate between biogenic and biomass burning (BB) dominated states. The Amazon further represents one of the few remaining continental places where the atmosphere approaches pristine conditions during occasional wet season episodes. The Amazon Tall Tower Observatory (ATTO) has been established in central Amazonia to investigate the complex interactions between the rainforest ecosystem and the atmosphere. Physical and chemical aerosol properties have been analyzed continuously since 2012. This paper provides an in-depth analysis of t…

Impact of asymptomatic COVID-19 patients in global surgical practice during the COVID-19 pandemic

The rapid spread of COVID-19 has changed the global surgical care. Patients infected with COVID-19 may present without typical symptoms, and such asymptomatic patients may potentially trigger in-hospital outbreaks by transmitting the disease to health care providers and other hospitalized patients. Further, asymptomatic COVID-19 patients have worse postop- erative outcomes with an unexpectedly high morbidity and mortality, reaching 20⋅5 per cent deaths. However, we do not have objective global data on this issue. In an attempt to clarify the current global surgical practice under the COVID-19 pandemic particularly focusing on the preoperative screening of asymptomatic COVID-19 patients, we …

Land cover and its transformation in the backward trajectory footprint region of the Amazon Tall Tower Observatory

Abstract. The Amazon rain forest experiences the combined pressures from human-made deforestation and progressing climate change, causing severe and potentially disruptive perturbations of the ecosystem's integrity and stability. To intensify research on critical aspects of Amazonian biosphere–atmosphere exchange, the Amazon Tall Tower Observatory (ATTO) has been established in the central Amazon Basin. Here we present a multi-year analysis of backward trajectories to derive an effective footprint region of the observatory, which spans large parts of the particularly vulnerable eastern basin. Further, we characterize geospatial properties of the footprint regions, such as climatic condition…

First observation of the isospin violating decay $J/\psi\rightarrow \Lambda\bar{\Sigma}^{0}+c.c.$

Using a sample of $(225.2\pm 2.8)\times 10^6$ $J/\psi$ events collected with the BESIII detector, we present results of a study of $J/\psi\rightarrow \gamma\Lambda\bar{\Lambda}$ and report the first observation of the isospin violating decay $J/\psi\rightarrow\Lambda\bar{\Sigma}^{0}+c.c.$, in which $\bar{\Sigma}^{0}$ decays to $\gamma \bar{\Lambda}$. The measured branching fractions are $\mathcal{B}(J/\psi\rightarrow\bar{\Lambda}\Sigma^{0}$) = $(1.46\pm0.11\pm0.12) \times10^{-5}$ and $\mathcal{B}(J/\psi\rightarrow\Lambda\bar{\Sigma^{0}}$) = $(1.37\pm0.12\pm0.11) \times10^{-5}$. We search for $\Lambda(1520) \rightarrow \gamma \Lambda$ decay, and find no evident signal, and an upper limit for…

Influx of African biomass burning aerosol during the Amazonian dry season through layered transatlantic transport of black carbon-rich smoke

Black carbon (BC) aerosols influence the Earth's atmosphere and climate, but their microphysical properties, spatiotemporal distribution, and long-range transport are not well constrained. This study presents airborne observations of the transatlantic transport of BC-rich African biomass burning (BB) smoke into the Amazon Basin using a Single Particle Soot Photometer (SP2) as well as several complementary techniques. We base our results on observations of aerosols and trace gases off the Brazilian coast onboard the HALO (High Altitude and LOng range) research aircraft during the ACRIDICON-CHUVA campaign in September 2014. During flight AC19 over land and ocean at the northeastern coastline …

Organic carbon and nitrogen stable isotopes in the intertidal sediments from the Yangtze Estuary, China

The natural isotopic compositions and C/N elemental ratios of sedimentary organic matter were determined in the intertidal flat of the Yangtze Estuary. The results showed that the ratios of carbon and nitrogen stable isotopes were respectively -29.8 per thousand to -26.0 per thousand and 1.6 per thousand-5.5 per thousand in the flood season (July), while they were -27.3 per thousand to -25.6 per thousand and 1.7 per thousand-7.8 per thousand in the dry season (February), respectively. The delta(13)C signatures were remarkably higher in July than in February, and gradually increased from the freshwater areas to the brackish areas. In contrast, there were relatively complex seasonal and spati…

Evidence for the Direct Two-Photon Transition from $\psi(3686)$ to $J/\psi$

The two-photon transition $\psi(3686)\to\gamma\gamma J/\psi$ is studied in a sample of 106 million $\psi(3686)$ decays collected by the BESIII detector. The branching fraction is measured to be $(3.1\pm0.6(\unit{stat})^{+0.8}_{-1.0}(\unit{syst})) \times10^{-4}$ using $J/\psi\to e^+e^-$ and $J/\psi\to\mu^+\mu^-$ decays, and its upper limit is estimated to be $4.5\times10^{-4}$ at the 90% conference level. This work represents the first measurement of a two-photon transition among charmonium states. The orientation of the $\psi(3686)$ decay plane and the $J/\psi$ polarization in this decay are also studied. In addition, the product branching fractions of sequential $E1$ transitions $\psi(3686…

Search for neutral MSSM Higgs bosons at LEP

The four LEP collaborations, ALEPH, DELPHI, L3 and OPAL, have searched for the neutral Higgs bosons which are predicted by the Minimal Supersymmetric Standard Model (MSSM). The data of the four collaborations are statistically combined and examined for their consistency with the background hypothesis and with a possible Higgs boson signal. The combined LEP data show no significant excess of events which would indicate the production of Higgs bosons. The search results are used to set upper bounds on the cross-sections of various Higgs-like event topologies. The results are interpreted within the MSSM in a number of "benchmark" models, including CP-conserving and CP-violating scenarios. Thes…