Large-scale genotyping identifies 41 new loci associated with breast cancer risk

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RESEARCH PRODUCT

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

K. Michailidou P. Hall A. Gonzalez-neira M. Ghoussaini J. Dennis R.l. Milne M.k. Schmidt J. Chang-claude S.e. Bojesen M.k. Bolla Q. Wang E. Dicks A. Lee C. Turnbull N. Rahman O. Fletcher J. Peto L. Gibson I.d. Silva H. Nevanlinna T.a. Muranen K. Aittomaki C. Blomqvist K. Czene A. Irwanto J.j. Liu Q. Waisfisz H. Meijers-heijboer M. Adank R.b. Van Der Luijt R. Hein N. Dahmen L. Beckman A. Meindl R.k. Schmutzler B. Muller-myhsok P. Lichtner J.l. Hopper M.c. Southey E. Makalic D.f. Schmidt A.g. Uitterlinden A. Hofman D.j. Hunter S.j. Chanock D. Vincent F. Bacot D.c. Tessier S. Canisius L.f.a. Wessels C.a. Haiman M. Shah R. Luben J. Brown C. Luccarini N. Schoof K. Humphreys J.m. Li B.g. Nordestgaard S.f. Nielsen H. Flyger F.j. Couch X.s. Wang C. Vachon K.n. Stevens D. Lambrechts M. Moisse R. Paridaens M.r. Christiaens A. Rudolph S. Nickels D. Flesch-janys N. Johnson Z. Aitken K. Aaltonen T. Heikkinen A. Broeks L.j. Van't Veer C.e. Van Der Schoot P. Guenel T. Truong P. Laurent-puig F. Menegaux F. Marme A. Schneeweiss C. Sohn B. Burwinke M.p. Zamora J.i.a. Perez G. Pita M.r. Alonso A. Cox I.w. Brock S.s. Cross M.w.r. Reed E.j. Sawyer I. Tomlinson M.j. Kerin N. Miller B.e. Henderson F. Schumacher L. Le Marchand I.l. Andrulis J.a. Knight G. Glendon A.m. Mulligan A. Lindblom S. Margolin M.j. Hooning A. Hollestelle A.m.w. Van Den Ouweland A. Jager Q.m. Bui J. Stone G.s. Dite C. Apicella H. Tsimiklis G.g. Giles G. Severi L. Baglietto P.a. Fasching L. Haeberle A.b. Ekici M.w. Beckmann H. Brenner H. Muller V. Arndt C. Stegmaier A. Swerdlown A. Ashworth N. Orr M. Jones J. Figueroa J. Lissowska L. Brinton M.s. Goldberg F. Labreche M. Dumont R. Winqvist K. Pylkas A. Jukkola-vuorinen M. Grip H. Brauch U. Hamann T. Bruning P. Radice P. Peterlongo S. Manouldan B. Bonanni P. Devilee R.a.e.m. Tollenaar C. Seynaeve C.j. Van Asperen A. Jakubowska J. Lubinski K. Jaworska K. Durda A. Mannermaa V. Kataja V.m. Kosma J.m. Hartikainen N.v. Bogdanova N.n. Antonenkova T. Dork V.n. Kristensen H. Anton-culver S. Slager A.e. Toland S. Edge F. Fostira D. Kang K.y. Yoo D.y. Noh K. Matsuo H. Ito H. Iwata A. Sueta A.h. Wu C.c. Tseng D. Van Den Berg D.o. Stram X.o. Shu W. Lu Y.t. Gao H. Cai S.h. Teo C.h. Yip S.y. Phuah B.k. Cornes M. Hartman H. Miao W.y. Lim J.h. Sng K. Muir A. Lophatananon S. Stewart-brown P. Siriwanarangsan C.y. Shen C.n. Hsiung P.e. Wu S.l. Ding S. Sangrajrang V. Gaborieau P. Brennan J. Mckay W.j. Blot L.b. Signorello Q.y. Cai W. Zheng S. Deming-halverson M. Shrubsole J.r. Long J. Simard M. Garcia-closas P.d.p. Pharoah G. Chenevix-trench A.m. Dunning J. Benitez D.f. Easton Breast Ovarian Canc Susceptibility Hereditary Breast Ovarian Canc Res Kconfab Investigators Australian Ovarian Can Study Grp Genica Gene Environm Interaction B

subject

signaling pathway Genotyping Genotype Single-nucleotide polymorphism Genome-wide association study Breast Neoplasms consortium Biology Breast Neoplasms; Case-Control Studies; Cooperative Behavior; Female; Gene-Environment Interaction; Genetic Loci; Genome-Wide Association Study; Genotype; Humans; Meta-Analysis as Topic; Polymorphism Single Nucleotide; Risk Factors; Genetic Predisposition to Disease; Genetics Polymorphism Single Nucleotide Article 03 medical and health sciences 0302 clinical medicine Breast cancer SDG 3 - Good Health and Well-being Meta-Analysis as Topic Risk Factors Genotype common variants expression Genetics medicine Humans Genetic Predisposition to Disease Polymorphism Cooperative Behavior gene Genotyping hormone-related protein 030304 developmental biology Genetic association Genetics 0303 health sciences Breast cancer susceptibility Cancer Single Nucleotide medicine.disease confer susceptibility susceptibility loci 3. Good health 14q24.1 rad51l1 TOX3 Genetic Loci 030220 oncology & carcinogenesis Case-Control Studies genome-wide association Female Gene-Environment Interaction Genome-Wide Association Study

description

Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10!¿8). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility. European Community Seventh Framework Programme - grant agreement 223175 (HEALTH-F2-2009-223175) (COGS) peer-reviewed

year	journal	country	edition	language
2013-04-30

10.1038/ng.2563 http://hdl.handle.net/10379/12885