0000000000300935
AUTHOR
D. Vincent
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborat…
Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.
Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the role of CASP8 in breast cancer susceptibility, we carried out dense genotyping of this region in the Breast Cancer Association Consortium (BCAC). Single-nucleotide polymorphisms (SNPs) spanning a 1 Mb region around CASP8 were genotyped in 46 450 breast cancer cases and 42 600 controls of European origin from 41 studies participating in the BCAC as part of a custom genotyping array experiment (iCOGS). Missing genotypes and SNPs were imputed and, after quality exclusions, 501 typed and 1232 imputed SNPs were included in logistic regressionmodels adjusting for stud…
A highly-segmented ΔE-time-of-flight wall as forward detector of the 4π-system for charged particles at the SIS/ESR accelerator
Abstract At the SIS/ESR accelerator facility at GSI in Darmstadt the 4π-detector system FOPI is under construction at present. It is designed for the investigation of central collisions of heavy ions in the energy range up to 2 A GeV. As phase I of this detector a forward wall has been built and used in various experiments. It comprizes a total number of 764 scintillators with an additional shell of 188 thin ΔE -detectors in front of it and covers the full azimuth of the polar angles from 1° to 30°. The velocity and the nuclear charge of the fragments are determined by a combined time-of-flight and ΔE measurement.