Blood flow, oxygen consumption and substrate utilization of human tumors xenotransplanted into nude rats

Human Mammary Carcinomas in Nude Rats — A New Approach for Investigating Oxygen Transport and Substrate Utilization in Tumor Tissues

An understanding of tumor pathophysiology with respect to blood flow, oxygenation status, pH distribution and utilization of the relevant substrates which, all together, critically influence growth kinetics and the efficiency of nonsurgical therapeutic modalities in vivo requires information derived directly from human malignant tissues. At present, only inadequate knowledge of the relevant physiological factors in tumor tissues of patients are accessible. The little data available to date were obtained from clinical observations rather than from systematic studies, i.e., data were collected from various tumor types with differing staging and grading. For this reason generally valid stateme…