Die lokale Fibrinolyse bei Nierenarterienverschlüssen

The indications and technique of local fibrinolysis therapy of acute renal artery occlusions are discussed in relation to four patients. Because of the short period for which ischaemia is tolerated by the kidney, the result of treatment depends largely on the time interval between occlusion and the beginning of treatment. Partial perfusion of the renal artery was obtained in three patients. Since the "ischaemia time" of the kidneys had been exceeded, it was not possible to obtain complete restitution of renal function in any of these patients.

Wachstumsverhalten duktaler Pankreascarcinome. In vivo- und in vitro-Untersuchungen

Unter den exokrinen Pankreasneoplasmen ist das duktale Adenocarcinom mit einer relativen Haufigkeit von 80–90% der vorherrschende Tumor (1). Durch seine generell schlechte Prognose, nur etwa 2% der behandelten Patienten uberleben die Funfjahresgrenze (2) und seine langsam zunehmende Incidenz in den letzten 20 Jahren (3), ist das duktale Pankreascarcinom zu einer grosen Herausforderung in der Onkologie geworden. An einem geeigneten Tumormodell wie dem “Nacktmaussystem” konnten Tumorbiologie, Tumorwachstum und pratherapeutische Therapiestudien untersucht werden. In der vorliegenden Arbeit sollte zunachst uberpruft werden, inwieweit das Wachstumsverhalten duktaler Pankreascarcinome auf der Nac…

Vergleich von Beckenangiographie, gepulster Dopplersonographie und penobrachialem Index in der Abklärung der erektilen Impotenz

Die Beckenangiographie galt bisher in der Abklarung der erektilen Dysfunktion zur Beurteilung der Penisgefase als Methode der Wahl [3]. Als Scree-ning-Untersuchung wird der penobrachiale Index (PBI) als nicht invasives diagnostisches Verfahren durchgefuhrt.

Beurteilung des Flüssigkeitsgehaltes der Lunge anhand des Thorax-Röntgenbildes: Vergleich der Messung des extravaskulären Lungenwassers und der Ergebnisse radiologischer Beurteilungsmethoden*

Extravascular lung water (EVLW) was determined with the thermal-dye double-indicator method (119 individual measurements) in 23 patients in an intensive-care unit, and the results were compared with estimates made from largely standardized portable chest X-ray films, using the staging method of Sibbald as well as that of Halperin. There was a significant correlation with the measured EVLW for both methods. Radiologically "normal" films corresponded to a mean EVLW value of 8.4 ml/kg body-weight. Radiologically judged adjacent stages did not in all cases compare with corresponding measured EVLW values. But when EVLW values were clearly abnormal, the X-ray films always demonstrated massive int…

Review article: Percutaneous transhepatic biliary drainage: Experience with 311 procedures

Percutaneous biliary drainage was performed in 296 patients on 311 occasions using a fine-needle puncture technique. In 59%, the procedure served as postoperative decompression, and in 35% for palliation of obstruction, particularly in malignant disease. Postoperative drainage for the management of postoperative complication accounted for 2.5%. In more than 80% of the patients treated, the underlying disease was malignant obstructive jaundice. In 257 retrospectively evaluated patients the following complications were observed: cholangitis (6.6%), sepsis (3.1%), bile leakage (1.6%) with two deaths (0.7%), and subcapsular hematoma and hematoma in the hepatoduodenal ligament (1.2%). Catheter d…

Therapie des Koronar-steal-Syndroms mittels perkutaner transluminaler Angioplastie

Probleme der Stadieneinteilung beim fortgeschrittenen Blasentumor

Eine bis zu 50% reichende Unterschatzung der Blasencarcinome in den Stadien pTa bis hin zum Stadium pT3a, eine uber 50% reichende Uberschatzung der Stadien pT3b und pT4 und eine richtige Aussage in nur 44% der Falle kennzeichnen die Problematik der exakten klinischen Stadienerfassung von Blasentumoren in der „Vor-CT-Aera“ [2].

Perkutane Entfernung von Schrittmachersonden

The large number of pace-makers introduced transvenously has resulted in increasing the number of complications, amongst which infections and dislocations are prominent. It is usually necessary to remove the electrode, which can be attempted percutaneously by using a Dormia basket, a loop or forceps. Amongst the complications of this procedure are tears to the myocardium, with the risk of pericardial tamponade, or tears of the tricuspid valve leading to tricuspid insufficiency. Consequently, thoracic surgical intervention should be available if necessary. Four successful procedures are described.

Der Supinatorfettkörper bei Frakturen des Ellbogengelenkes

The position of the supinator fat pad is regarded as a valuable sign in fractures of the elbow. In our patients the pad was visible in 277 out of 337 cases (82%). The sign was positive in only 27 out of 55 proximal fractures of the radius (sensitivity 0.49). There was no correlation between the severity of the fracture and the sign. There was marked variation in the distance between the pad and the radius, depending on age, build and projection. Our results indicate that the sign is not suitable for the diagnosis of fracture of the elbow.

Supplementary Material for: Distinct Signaling Cascades of TREM-1, TLR and NLR in Neutrophils and Monocytic Cells

Triggering receptor expressed on myeloid cells 1 (TREM-1) is an important mediator of innate inflammatory responses in microbial infections and sepsis. TREM-1 ligation on neutrophils (PMN) or monocytes results in the production of proinflammatory cytokines. Engagement of TREM-1 induces the activation of MAP kinases as well as rapid Ca2+ mobilization. However, a detailed understanding of TREM-1 signaling pathways is currently lacking. We evaluated the TREM-1 signaling hierarchy in monocytic cells and found that the acute myeloid leukemia cell line MUTZ-3 expresses TREM-1 in a natural and functional manner. We compared essential signaling molecules of the TREM-1, TLR and NLR cascade in MUTZ-3…

Supplementary Material for: Signaling Pathways of the TREM-1- and TLR4-Mediated Neutrophil Oxidative Burst

The triggering receptor expressed on myeloid cells 1 (TREM-1) is involved in the innate inflammatory response to microbial infections. Activation and expression of TREM-1 by polymorphonuclear neutrophils (PMN) occurs in concert with Toll-like receptors (TLR) such as TLR4 for bacterial lipopolysaccharide. However, it is currently unclear how this is mediated on a molecular level. Using pharmacological inhibitors and Western blot analysis we demonstrate that phosphatidyl inositide 3-kinase, phospholipase C and the mitogen-activated kinase p38MAPK are essential for the TREM-1- and TLR4-induced oxidative burst of human PMN. The activation of protein kinase B and extracellular signal-related kin…