0000000000305882
AUTHOR
Elisabetta Sciacca
A feasibility analysis on the use of ultrasonic multihop communications for E-health applications
Rise in population aging as well as diffusion of chronic diseases and health consciousness require constant monitoring of health conditions but also lead to increasing costs for the governments. Body Area Networks represent the next frontier in health care and are envisaged as the natural choice to provide detailed and updated information on health status to prevent health risks and diseases. However if, on the one hand, a large research effort has been devoted so far to the investigation of BAN communications on and around the body, on the other hand intra-BAN communications are still a scarcely explored area because of the difficulties and risks in successfully propagating signals inside …
Recapitulating thyroid cancer histotypes through engineering embryonic stem cells
AbstractThyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell subpopulation in the lineage hierarchy that serves as cell of origin for the different TC histotypes is unknown. Human embryonic stem cells (hESCs) with appropriate in vitro stimulation undergo sequential differentiation into thyroid progenitor cells (TPCs-day 22), which maturate into thyrocytes (day 30). Here, we create follicular cell-derived TCs of all the different histotypes based on specific genomic alterations delivered by CRISPR-Cas9 in hESC-derived TPCs. Specifically, TPCs harboring BRAFV600E or NRASQ61R mutations generate papillary or follicular TC, respectively, whereas addition of TP53R248…