0000000000306957

AUTHOR

Laia Torres-masjoan

showing 2 related works from this author

Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming

2021

Region-specific gene expression shared with neurons imparts to astrocytes competence for region-specific neuronal reprogramming.

EpigenomicsCellThalamusNeocortexBiology03 medical and health sciences0302 clinical medicineThalamusGene expressionmedicineEpigeneticsProgenitor cellNeural cellResearch Articles030304 developmental biologyNeurons0303 health sciencesMultidisciplinaryNeocortexSciAdv r-articlesmedicine.anatomical_structurenervous systemAstrocytesNeuroscienceReprogramming030217 neurology & neurosurgeryResearch ArticleNeuroscience
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Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system.

2018

Developing the bloodbrain barrier During development, signals need to be dynamically integrated by endothelial cells, neurons, and glia to achieve functional neuro-glia-vascular units in the central nervous system. During cortical development, neuronal Dab1 and ApoER2 receptors respond to a guidance cue called reelin. Studying mice, Segarra et al. found that Dab1 and ApoER2 are also expressed in endothelial cells (see the Perspective by Thomas). The integration of reelin signaling in endothelial cells and neurons facilitates the communication between vessels, glia, and neurons that is necessary for the correct positioning of neurons during cortical development. This integration is also impo…

0301 basic medicineMaleCell signalingLow-density lipoprotein receptor-related protein 8EndotheliumCell Adhesion Molecules NeuronalCentral nervous systemNeovascularization PhysiologicNerve Tissue ProteinsCell Communication03 medical and health sciencesMiceCell MovementmedicineAnimalsReelinLDL-Receptor Related ProteinsCerebral CortexMice KnockoutNeuronsRetinaExtracellular Matrix ProteinsMultidisciplinarybiologyIntegrin beta1Serine EndopeptidasesRetinal VesselsDAB1Reelin Protein030104 developmental biologymedicine.anatomical_structurenervous systemCerebral cortexBlood-Brain Barrierbiology.proteinFemaleEndothelium VascularLamininNeuroscienceNeurogliaGene DeletionSignal TransductionScience (New York, N.Y.)
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