6533b82efe1ef96bd1293307

RESEARCH PRODUCT

Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system.

Ioanna BethaniF. CopMiriam DammMiriam DammAmparo Acker-palmerAmparo Acker-palmerAmparo Acker-palmerMarta SegarraCecilia Llaó-cidMathias RitterMarta ParrillaMarta ParrillaLaura MohrAnne SchänzerRicarda HärtlTill AckerDewi HusainieDewi HusainieMaría Rodríguez AburtoMaría Rodríguez AburtoLaia Torres-masjoanHannah Schlierbach

subject

0301 basic medicineMaleCell signalingLow-density lipoprotein receptor-related protein 8EndotheliumCell Adhesion Molecules NeuronalCentral nervous systemNeovascularization PhysiologicNerve Tissue ProteinsCell Communication03 medical and health sciencesMiceCell MovementmedicineAnimalsReelinLDL-Receptor Related ProteinsCerebral CortexMice KnockoutNeuronsRetinaExtracellular Matrix ProteinsMultidisciplinarybiologyIntegrin beta1Serine EndopeptidasesRetinal VesselsDAB1Reelin Protein030104 developmental biologymedicine.anatomical_structurenervous systemCerebral cortexBlood-Brain Barrierbiology.proteinFemaleEndothelium VascularLamininNeuroscienceNeurogliaGene DeletionSignal Transduction

description

Developing the bloodbrain barrier During development, signals need to be dynamically integrated by endothelial cells, neurons, and glia to achieve functional neuro-glia-vascular units in the central nervous system. During cortical development, neuronal Dab1 and ApoER2 receptors respond to a guidance cue called reelin. Studying mice, Segarra et al. found that Dab1 and ApoER2 are also expressed in endothelial cells (see the Perspective by Thomas). The integration of reelin signaling in endothelial cells and neurons facilitates the communication between vessels, glia, and neurons that is necessary for the correct positioning of neurons during cortical development. This integration is also important for correct communication at the neurovascular unit required for blood-brain barrier integrity in the mature brain. Science , this issue p. eaao2861 ; see also p. 754

yearjournalcountryeditionlanguage
2018-08-24Science (New York, N.Y.)
10.1126/science.aao2861https://pubmed.ncbi.nlm.nih.gov/30139860