0000000000307171
AUTHOR
Mingyue Zhang
Dysregulated Expression of Neuregulin-1 by Cortical Pyramidal Neurons Disrupts Synaptic Plasticity
Summary Neuregulin-1 ( NRG1 ) gene variants are associated with increased genetic risk for schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased expression of NRG1 in the brains of schizophrenia patients, given that both findings have been reported from autopsy studies. To study NRG1 functions in vivo, we generated mouse mutants with reduced and elevated NRG1 levels and analyzed the impact on cortical functions. Loss of NRG1 from cortical projection neurons resulted in increased inhibitory neurotransmission, reduced synaptic plasticity, and hypoactivity. Neuronal overexpression of cysteine-rich domain (CRD)-NRG1, the major brain isoform, caused unbalanced excitato…
The role of evanescent modes in Global-Local analysis of UGW in plates with varying local zone-scatterer relations
In order to provide a reliable and robust SHM performance, Ultrasonic Guided Waves (UGWs) need to be analyzed and understood. Numerical modeling of UGW propagation and scattering by hybrid methods offers the possibility of simulating UGW interaction with waveguides of arbitrary cross-sections and discontinuities. Maximizing the accuracy of such methods is important to perform quantitative SHM, while maintaining minimum computational cost. This work investigates the role of evanescent modes in the numerical analysis of UGWs in aluminum and composite plates with defects, by the hybrid Global-Local method. The complex solutions to the UGW eigenvalue problem are found and the scattering spectra…