0000000000307394
AUTHOR
Dirk Breitmeier
Human Obesity Reduces the Number of Hepatic Leptin Receptor (Ob-R) Expressing NK Cells
In the industrialized world, obesity is an increasing socioeconomic health problem. Obese subjects have a higher risk of developing several types of cancer. NK cells are an integral component of the innate immune system, able to destruct tumor cells. The adipokine leptin plays a crucial role in the development of obesity and its related diseases. Peripheral leptin signaling is modulated by the liver.The aim of this study was to evaluate the number of hepatic NK cells (CD56+) and the number of leptin-receptor positive (Ob-R+) cells in the livers of five normal-weight and five obese humans. Livers were removed during autopsy and accurately defined sections were stained immunohistochemically a…
Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5)
The clitoris contributes to the normal female sexual response cycle. A significance of cyclic guanosine monophosphate (GMP) has been assumed in the control of clitoral vascular smooth muscle. As only a few investigations on the physiology of the vascular and non-vascular clitoral tissue have been carried out, knowledge on the mechanisms controlling this particular female genital organ is still vague. It has been suggested that human clitoral corpus cavernosum smooth muscle is regulated by nitric oxide (NO)/cyclic GMP and related key enzymes, such as NO synthases (NOSs) and the phosphodiesterase type 5 (PDE5). The present study evaluated in the human clitoris, by means of immunohistochemistr…
Analysis of metacarpal V fractures of an interdisciplinary emergency room of an urban German hospital from a forensic viewpoint
Metacarpal V fractures, especially metacarpal neck fractures, are known to the forensic society as a ‘boxer’s fracture’ and are described as being mostly caused by punching an immovable or firm object with force with a closed fist. To our knowledge there is no larger study that examines these fractures under forensic considerations of epidemiology. Our study includes the analysis of metacarpal V fractures in an interdisciplinary, academic and university-affiliated emergency department of an urban hospital over a period of three years. Emergency data sheets were systematically analysed and X-rays evaluated. The results were compared with the existing literature.