0000000000308418

AUTHOR

Laura Remesal

showing 2 related works from this author

Estudio de la función de los factores de transcripción PBX en la diferenciación a neurona dopaminérgica del bulbo olfatorio de ratón

2017

[EN] Dopamine signalling regulates a variety of complex behaviours and defects in dopaminergic neuron function or survival result in severe human pathologies such as Parkinson´s disease. All dopaminergic neurons are characterized by the expression of a battery of genes that code for a set of proteins required for the synthesis, release and re-uptake of dopamine and all together are called the DA pathway genes. Therefore, understanding how this set of genes are transcriptionally activated in a coordinated manner is the first step to discover the clues of dopaminergic terminal differentiation. The dopamine pathway genes are highly conserved throughout evolution. Studies in the nematode C.eleg…

242103nervous system240905diferenciación terminalneuronasdopaminapbxbulbo olfatorio
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PBX1 acts as terminal selector for olfactory bulb dopaminergic neurons

2020

15 páginas, 8 figuras. Supplementary information available online at http://dev.biologists.org/lookup/doi/10.1242/dev.186841.supplemental

MaleInterneuronCell SurvivalNeurogenesisRNA SplicingNeuron differentiationMitosisBiologyAdult neurogenesis03 medical and health sciencesOlfactory bulb0302 clinical medicineNeuroblastInterneuronsmedicineAnimalsProtein IsoformsCell LineageProgenitor cellTerminal selector10. No inequalityMolecular BiologyTranscription factorBody Patterning030304 developmental biologyMice KnockoutDopaminergic neuron0303 health sciencesDopaminergic NeuronsPre-B-Cell Leukemia Transcription Factor 1fungiNeurogenesisDopaminergicCell DifferentiationExonsEmbryo Mammalian3. Good healthOlfactory bulbmedicine.anatomical_structureMutationNeuron differentiationNeuroscience030217 neurology & neurosurgeryTranscription FactorsAlternative splicingDevelopmental BiologyDevelopment
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