Incidencia de cáncer cutáneo distinto del melanoma en pacientes tratados con PUVA oral

Resumen Introduccion Los trabajos que determinan la incidencia de cancer cutaneo no melanoma (CCNM) en la poblacion tratada con psoralenos orales + UVA son heterogeneos, dependen de la localizacion geografica de la poblacion estudiada y tienen periodos de seguimiento cortos. El objetivo del trabajo es determinar la seguridad a largo plazo de la PUVAterapia y en concreto determinar la incidencia de CCNM en los pacientes tratados con PUVAterapia oral en el area mediterranea. Material y metodo Se ha realizado un estudio longitudinal de seguimiento retrospectivo, recogiendo 234 pacientes tratados con PUVA sistemico entre 1982 y 1996 con un seguimiento hasta mayo de 2017. Se ha calculado la dens…

Interferon alfa–induced sarcoidosis resolving without drug withdrawal

Sarcoidosis is an uncommon systemic granulomatous disease of unknown origin affecting lung, skin, liver, and other tissues. Noncaseating granulomas in the involved organs are the hallmark of this disease. An exaggerated immune response to an unknown antigenic stimulus could play a role in sarcoidosis development. Lung is one of the most frequently involved organs.1 Manifestations range from alveolitis to granulomatous infiltration of alveoli, bronchi, and blood vessels. The end stage of lung sarcoidosis is development of interstitial fibrosis with “honeycombing” of lung parenchyma. Interferon alfa in association with ribavirin is the treatment of choice for hepatitis C. Early treatment of a…

Hiperpigmentación puntiforme como manifestación de fitofotodermatosis por lima

Herpes zóster posvacunal: valor del citodiagnóstico de Tzank

Incidence of non-melanoma skin cancer in patients treated with psoralen and ultraviolet A therapy.

Abstract Introduction Studies reporting incidences of non-melanoma skin cancer (NMSC) are heterogeneous, depend on the geographic area of the studied population and are often short-term. The aim of this study is to determine the incidence of NMSC in patients treated with oral PUVA therapy in the Mediterranean area. Material and methods A retrospective, observational study was carried out with a sample of 234 patients treated with systemic PUVA between 1982 and 1996, carrying out a historical follow-up until May 2017. The incidence density rate of CCNM (crude and adjusted) was calculated by direct standardisation. The incidence of CCNM was compared with that reported in the general populatio…