0000000000319486

AUTHOR

Giancarlo Maccagno

showing 2 related works from this author

Control Of Organ Transplant-Associated Graft-versus-Host Disease By Activated Host Lymphocyte Infusions

2004

Background Prolonged persistence of donor-derived T cells after organ transplantation has been proposed to improve long-term allograft survival. However, surviving transplant-derived T cells are also able to mediate devastating graft-versus-host disease (GvHD). Currently, GvHD after organ transplantation is usually refractory to conventional therapy and the disease outcome fatal. Methods Graft-reactive host T cells were generated ex vivo from a patient suffering from a severe and refractory liver-transplant-associated GvHD. To control GvHD, activated alloreactive host T cells were repetitively retransferred into the patient (activated host lymphocyte infusion [aHLI]). Results Adoptive trans…

medicine.medical_specialtyAdoptive cell transferLymphocytemedicine.medical_treatmentGraft vs Host Diseasechemical and pharmacologic phenomenaLymphocyte ActivationImmunotherapy AdoptiveSeverity of Illness IndexOrgan transplantationBlood Transfusion AutologousmedicineHumansAgedTransplantationbusiness.industryImmunotherapymedicine.diseaseAdoptive TransferLiver TransplantationTransplantationsurgical procedures operativeGraft-versus-host diseasemedicine.anatomical_structureLymphocyte TransfusionImmunologyFemaleStem cellEpidermolysis BullosabusinessEx vivoTransplantation
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Alloimmune hemolytic anemia after liver transplantation from an ABO-identical and Rh-nonidentical donor in a patient with postpartum Budd-Chiari synd…

2006

Hemolytic anemiamedicine.medical_specialtyTransplantationbusiness.industryABO blood group systemmedicine.medical_treatmentInternal medicinemedicineBudd–Chiari syndromeLiver transplantationmedicine.diseasebusinessGastroenterologyTransplant International
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