0000000000319904

AUTHOR

Tandis Keller

showing 1 related works from this author

Local transient myocardial liposomal gene transfer of inducible nitric oxide synthase does not aggravate myocardial function and fibrosis and leads t…

2010

Microcirculation (2010) 17, 69–78. doi: 10.1111/j.1549-8719.2010.00002.x Abstract Background:  This study was designed to explore the effect of transient inducible nitric oxide synthase (iNOS) overexpression via cationic liposome-mediated gene transfer on cardiac function, fibrosis, and microvascular perfusion in a porcine model of chronic ischemia. Methods and Results:  Chronic myocardial ischemia was induced using a minimally invasive model in 23 landrace pigs. Upon demonstration of heart failure, 10 animals were treated with liposome-mediated iNOS-gene-transfer by local intramyocardial injection and 13 animals received a sham procedure to serve as control. The efficacy of this iNOS-gene-…

Cardiac function curveMalemedicine.medical_specialtyPhysiologySus scrofaIschemiaMyocardial IschemiaGene ExpressionNitric Oxide Synthase Type IINitric OxideVentricular Function LeftNeovascularizationFibrosisPhysiology (medical)Internal medicinemedicineAnimalsHumansMolecular BiologyEjection fractionbiologyNeovascularization Pathologicbusiness.industryMyocardiumGene Transfer Techniquesmedicine.diseaseFibrosisMagnetic Resonance ImagingRecombinant ProteinsNitric oxide synthaseArteriolesHeart failureLiposomesCardiologybiology.proteinDobutamineFemalemedicine.symptomCardiology and Cardiovascular Medicinebusinessmedicine.drugMicrocirculation (New York, N.Y. : 1994)
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