0000000000320214
AUTHOR
Wei Su
showing 2 related works from this author
New physics implication of Higgs precision measurements
2018
Studying the properties of the Higgs boson can be an important window to explore the physics beyond the Standard Model (SM). In this work, we present studies on the implications of the Higgs precision measurements at future Higgs Factories. We perform a global fit to various Higgs search channels to obtain the 95 % C.L. constraints on the model parameter spaces of Two Higgs Double Model (2HDM) and Minimal Supersymmetric Standard Model (MSSM). In the 2HDM, we analyze tree level effects as well as one-loop contributions from the heavy Higgs bosons. The strong constraints on $\cos(\beta-\alpha)$, heavy Higgs masses and their mass splitting are complementary to direct search of the LHC as well …
Synthetic mRNAs with Superior Translation and Stability Properties
2012
The translational efficiency and stability of synthetic mRNA in both cultured cells and whole animals can be improved by incorporation of modified cap structures at the 5'-end. mRNAs are synthesized in vitro by a phage RNA polymerase transcribing a plasmid containing the mRNA sequence in the presence of all four NTPs plus a cap dinucleotide. Modifications in the cap dinucleotide at the 2'- or 3'-positions of m(7)Guo, or modifications in the polyphosphate chain, can improve both translational efficiency and stability of the mRNA, thereby increasing the amount and duration of protein expression. In the context of RNA-based immunotherapy, the latter is especially important for antigen producti…