0000000000320724
AUTHOR
Guarnotta V
Predictive factors of response to mTOR inhibitors in neuroendocrine tumours
Medical treatment of neuroendocrine tumours (NETs) has drawn a lot of attention due to the recent demonstration of efficacy of several drugs on progression-free survival, including somatostatin analogs, small tyrosine kinase inhibitors and mTOR inhibitors (or rapalogs). The latter are approved as therapeutic agents in advanced pancreatic NETs and have been demonstrated to be effective in different types of NETs, with variable efficacy due to the development of resistance to treatment. Early detection of patients that may benefit from rapalogs treatment is of paramount importance in order to select the better treatment and avoid ineffective and expensive treatments. Predictive markers for th…
Miglioramento dell'insulino-sensibilità e dell'insulino-secrezione dopo switch da terapia con glucocorticoidi tradizionali a idrocortisone "dual release" in pazienti affetti da iposurrenalismo
Background: La terapia sostitutiva con glucocorticoidi (GC) non riflette la fisiologica secrezione endogena di cortisolo per cui è spesso associata a numerose complicanze croniche, fra cui quelle metaboliche con tendenza all’aumento della glicemia e riduzione dell’insulino-sensibilità con secondario iperinsulinismo. Obiettivi: Valutare gli effetti metabolici dello switch da terapia con GC a rapido rilascio (idrocortisone e cortisone acetato) somministrati 2-3 volte/die alla monosomministrazione giornaliera di idrocortisone “dual release” (IDR) mantenendo la stessa dose bioequivalente. Metodi: Abbiamo valutato, oltre ai classici parametri clinici e metabolici, l’indice di insulino-sensibilit…
Body composition assessment for the definition of cardiometabolic risk.
Obesity is associated with a major prevalence of cardiovascular risk factors and high risk of cardiovascular events and contributes to the increase in cardiovascular morbidity and mortality worldwide. Beyond the fat mass per se, the pattern of fat distribution has a profound influence on cardiometabolic risk. The increase in abdominal adipose tissue confers an independent risk, while the amount of gluteofemoral body fat is thought to be protective. Changes in the capacity of different depots to store and release fatty acids and to produce adipocytokines are important determinants of fat distribution and its metabolic consequences. Because of the complexity of the assessment of body fat with…