0000000000322048
AUTHOR
Jan Lochman
showing 2 related works from this author
Perception of elicitins by receptor complex in solanaceae
2022
Extensive infections of crop plants by plant pathogens have repeatedly resulted in catastrophic harvest failures causing major economic and social problems worldwide. Successful plant defence against pathogens is based on early microbe recognition and fast activation of downstream immune signalling (e.g. phosphorylations, production of reactive oxygen species, transcriptomic reprogramming). Plant surface pattern-recognition receptors (PRRs) act as initial detectors that can recognise microbial-associated molecular patterns (MAMPs) to induce the basal resistance response called MAMP-triggered immunity (MTI). Despite the increasing number of PRRs discovered in the past 20 years, for most of t…
CD36 gene polymorphism is associated with Alzheimer's disease.
2017
IF 3.112; International audience; CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously i…