CD36 gene polymorphism is associated with Alzheimer's disease.

6533b821fe1ef96bd127c386

RESEARCH PRODUCT

CD36 gene polymorphism is associated with Alzheimer's disease.

Vladimir J. Balcar Vladimir J. Balcar Alice Hálová Alice Hálová Vladimir Janout Laura Ewerlingová Laura Ewerlingová Jan Lochman Jana Janoutová Naim Akhtar Khan Omar ŠErý Omar ŠErý

subject

0301 basic medicine Apolipoprotein E MESH : Oxidative Stress CD36 Antigens Male MESH : Polymorphism Genetic CD36 MESH : Aged MESH : Alzheimer Disease MESH : Genotype Biochemistry Gene MESH: Genotype 0302 clinical medicine MESH: Cholesterol MESH : Female MESH : Cholesterol Genetics MESH: Aged MESH: Oxidative Stress biology MESH: Polymorphism Single Nucleotide MESH : Polymorphism Single Nucleotide MESH: Genetic Predisposition to Disease General Medicine 3. Good health MESH : Antigens CD36 Cholesterol Interleukin 18 Female ApoE Genotype MESH : Male Single-nucleotide polymorphism Polymorphism Single Nucleotide MMSE Association 03 medical and health sciences Alzheimer Disease MESH: Polymorphism Genetic SNP Humans Genetic Predisposition to Disease [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Allele Polymorphism [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular Biology Genetic association Aged Polymorphism Genetic MESH: Humans MESH: Antigens CD36 MESH : Humans MESH: Male Oxidative Stress 030104 developmental biology biology.protein MESH : Genetic Predisposition to Disease Gene polymorphism CD36 MESH: Female 030217 neurology & neurosurgery MESH: Alzheimer Disease

description

IF 3.112; International audience; CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.

year	journal	country	edition	language
2017-04-01

10.1016/j.biochi.2017.01.009 https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01555390