0000000000322985

AUTHOR

Anne Philippe

showing 2 related works from this author

Statistical inference and Monte Carlo algorithms

1996

This review article looks at a small part of the picture of the interrelationship between statistical theory and computational algorithms, especially the Gibbs sampler and the Accept-Reject algorithm. We pay particular attention to how the methodologies affect and complement each other.

Statistics and ProbabilityDecision theoryMonte Carlo methodMarkov chain Monte CarloStatistics::ComputationComplement (complexity)symbols.namesakeStatistical inferencesymbolsMonte Carlo method in statistical physicsStatistics Probability and UncertaintyStatistical theoryAlgorithmGibbs samplingMathematicsTest
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Genetic counselling difficulties and ethical implications of incidental findings from array-CGH: a 7-year national survey

2016

Microarray-based comparative genomic hybridization (aCGH) is commonly used in diagnosing patients with intellectual disability (ID) with or without congenital malformation. Because aCGH interrogates with the whole genome, there is a risk of being confronted with incidental findings (IF). In order to anticipate the ethical issues of IF with the generalization of new genome-wide analysis technologies, we questioned French clinicians and cytogeneticists about the situations they have faced regarding IF from aCGH. Sixty-five IF were reported. Forty corresponded to autosomal dominant diseases with incomplete penetrance, 7 to autosomal dominant diseases with complete penetrance, 14 to X-linked di…

0301 basic medicineGeneticsmedicine.medical_specialtyeducation.field_of_studyEthical issuesbusiness.industryGenetic counselingPopulationRetrospective cohort study030105 genetics & hereditymedicine.diseasePenetrance3. Good health03 medical and health sciencesGeneralization (learning)Family medicineIntellectual disabilityGeneticsMedicinebusinesseducationGenetics (clinical)Comparative genomic hybridizationClinical Genetics
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