0000000000323642

AUTHOR

Maria Pilar Garcillán-barcia

showing 3 related works from this author

Genomic analysis of the emergence and evolution of multidrug resistance during a Klebsiella pneumoniae outbreak including carbapenem and colistin res…

2014

et al.

AdultDNA BacterialMaleMicrobiology (medical)CarbapenemAntibiotic resistanceKlebsiella pneumoniaeMolecular Sequence DataNonsense mutationFosfomycinDisease OutbreaksMicrobiologyEvolution MolecularPlasmidAntibiotic resistanceMutation RateOutbreak genomicsmedicineHumansPharmacology (medical)AgedPharmacologyGeneticsbiologyColistinHypermutationSequence Analysis DNAMiddle Agedbiochemical phenomena metabolism and nutritionbiology.organism_classificationDrug Resistance MultipleAnti-Bacterial AgentsKlebsiella InfectionsMultiple drug resistanceKlebsiella pneumoniaeInfectious DiseasesCarbapenemsKlebsiella pneumoniae genomeColistinbacteriaFemaleGenome Bacterialmedicine.drugJournal of Antimicrobial Chemotherapy
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Blueprint for a minimal photoautotrophic cell: conserved and variable genes in Synechococcus elongatus PCC 7942.

2011

This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al.

lcsh:QH426-470Gene Transfer HorizontalGenomic IslandsOperonlcsh:BiotechnologyComputingMilieux_LEGALASPECTSOFCOMPUTINGmacromolecular substancesGenome03 medical and health sciencesOpen Reading FramesBacterial ProteinsBacterial proteinslcsh:TP248.13-248.65Genomic islandGeneticsGenomic islandsGeneGenome sizeGene transferPhylogeny030304 developmental biologyGeneticsSynechococcus0303 health sciencesBase CompositionGenomebiology030302 biochemistry & molecular biologySynechococcusbiology.organism_classification3. Good healthlcsh:GeneticsCodon usage biasHorizontal gene transferbacteriaGenome BacterialBiotechnologyResearch ArticleBMC genomics
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Toward minimal bacterial cells: evolution vs. design.

2008

Abstract Recent technical and conceptual advances in the biological sciences opened the possibility of the construction of newly designed cells. In this paper we review the state of the art of cell engineering in the context of genome research, paying particular attention to what we can learn on naturally reduced genomes from either symbiotic or free living bacteria. Different minimal hypothetically viable cells can be defined on the basis of several computational and experimental approaches. Projects aiming at simplifying living cells converge with efforts to make synthetic genomes for minimal cells. The panorama of this particular view of synthetic biology lead us to consider the use of d…

Cell engineeringContext (language use)BiologyMicrobiologyGenomeArticleEvolution MolecularSynthetic biologyGenome researchGenes SyntheticBiological sciencesreduced genomesEvolution ChemicalBacteriasynthetic cellbusiness.industrysynthetic genomeComputational BiologyBiotechnologyInfectious DiseasesMinimal genomeBiochemical engineeringsynthetic biologybusinessFree living bacteriaGenome Bacterialminimal genomeFEMS microbiology reviews
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