Influence of Different Methods to Estimate the Glomerular Filtration Rate on the Prevalence of Decreased Renal Function in Arterial Hypertension

Associazione tra variabilità glicemica (ottenuta attraverso il monitoraggio glicemico continuo delle 48h) ed interleukina-6 in soggetti con sindrome metabolica

Influence of different methods to estimate glomerular filtration rate on the prevalence of decreased renal function in essential hypertension. Preliminary results of the REDHY study.

Secondary Hyperparathyroidism and renal transplantation.

Variabilità glicemica da monitoraggio continuo delle 48h ed interleukina-6 in soggetti con sindrome metabolica

In renal transplanted patients inflammation and oxidative stress are interrelated.

Introduction: The inflammatory state plays a well-documented role to cause oxidative stress, especially in end-stage renal disease (ESRD) patients, wherein several cardiovascular risk factors are amplified by the coexistence of a microinflammatory state with increased oxidative stress. Methods: We measured serum concentrations of high sensitivity C-reactive protein (CRP), tumor necrosis factor α (TNFα), 8-iso-prostaglandin F2α (8-iso-PGF2α-in vivo oxidative stress marker) in 15 chronic renal failure (CRF) and 15 transplant patients versus 15 healthy controls. Exclusion criteria were: age 65 years as well as a diagnosis of diabetes or cardiovascular diseases. We evaluated systolic (SBP) and …

Glycaemic variability (measured by 48h continous glucose monitoring) in subjects with metabolic syndrome, with ot withoout diabetes,is indipendently associated with IL-6 bood concentrations

Postprandial hyperglycaemia induces endothelial dysfunction thus contributing to the appearance of atherosclerotic lesions and to the high cardiovascular risk of diabetic subjects. Subjects who develop diabetes have an increased cardiovascular risk even before the appearance of diabetes. Insulin resistant subjects with metabolic syndrome (MS) are at both high cardiovascular and diabetes risk and it cannot be excluded that higher postprandial glycaemic excursions might induce endothelial dysfunction in this condition. Furthermore, adipose tissue is known to release factors (adipokines) that are able to influence both insulin sensitivity and endothelial function. The glycaemic variability is …

Oxidative stress and inflammation in long-term renal transplanted hypertensives.

INTRODUCTION Several studies have shown that chronic renal failure (CRF) is characterized by "accelerated atherosclerosis". More recent studies emphasize that inflammation and oxidative stress play a central role in atherosclerosis, and it is well-established that C-reactive protein (CRP) is a cardiovascular risk marker in the general population, in end-stage renal disease (ESRD) patients and in allograft recipients. METHODS We measured the serum concentration of high sensitivity CRP, TNFalpha, 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha, an in vivo oxidative stress marker) in 15 CRF patients and in 15 transplant recipients. Exclusion criteria were age 65 years, smoking, diabetes mellitus …

Resistenze intra-renali, spessore mio-intimale carotideo ed interleukina-6 in soggetti con sindrome metabolica

Influenza di differenti metodi di stima del filtrato glomerulare sulla prevalenza della riduzione lieve e moderata della funzione renale nell’ipertensione arteriosa non complicata. Risultati preliminari dello studio REDHY.

(2006). Oxidant stress and endothelial activation in hypertensive patients with and without left ventricular hypertrophy.

Infiammazione e stress ossidativo: confronto tra pazienti con insufficienza renale cronica e pazienti sottoposti a trapianto renale

Influenza di differenti metodi di stima del filtrato glomerulare sulla prevalenza della riduzione della funzione renale nell’ipertensione arteriosa non complicata.

Confronto a breve e medio termine tra dieta ipocalorica ipoglucidica ed ipocalorica mediterranea sulla funzione endoteliale. Risultati preliminari. (ISRCTN 53451414)

Glycaemic variability (measured by 48h continuous glucose monitoring) in subjects with metabolic syndrome, with or without diabetes, is independently associated with IL-6 blood concentrations.

Secondary Hyperparathyroidism and renal tranplantation

La distribuzione corporea del grasso influenza le resistenze intra-renali e lo spessore intima media carotideo nei soggetti con e senza sindrome metabolica