0000000000324290

AUTHOR

G. Koller

showing 4 related works from this author

No association of alcohol dependence with HOMER 1 and 2 genetic variants.

2010

Several lines of evidence indicate that alterations of the central cortico-accumbens glutamate pathway are involved in the development and maintenance of alcohol- and substance-use disorders. The HOMER protein family is encoded by 3 genes HOMER (1–3) which are components of the excitatory postsynaptic density complex and function to modulate synaptic activity by the regulation of glutamate signaling. HOMER 1 and 2 have been reported to contribute to chronic alcohol-induced long-term neurochemical changes in the endogenous reward system. Data from animal models suggest a potential role of the Homer protein family in the development of alcohol and substance use. The aim of this study is to as…

AdultMaleLinkage disequilibriumSingle-nucleotide polymorphismBiologyPolymorphism Single NucleotideLinkage DisequilibriumCellular and Molecular NeuroscienceGene FrequencyHomer Scaffolding ProteinsGenotypeGenetic variationSNPHumansGenetic Predisposition to DiseaseAlleleGenetics (clinical)GeneticsAlcohol dependenceHaplotypePsychiatry and Mental healthAlcoholismHaplotypesCase-Control StudiesFemaleCarrier ProteinsAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
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Association of functional DBH genetic variants with alcohol dependence risk and related depression and suicide attempt phenotypes: Results from a lar…

2012

Abstract Objective Dopamine-beta-hydroxylase (DBH) metabolizes the conversion of dopamine to noradrenaline. DBH, located on chromosome 9q34.2 has variants with potential functional consequences which may be related to alterations of neurotransmitter function and several psychiatric phenotypes, including alcohol dependence (AD), depression (MD) and suicidal behavior (SA). The aim of this association study in a large multicenter sample of alcohol-dependent individuals and controls is to investigate the role of DBH SNPs and haplotypes in AD risk and associated phenotypes (AD with MD or SA). Method 1606 inpatient subjects with DSM-IV AD from four addiction treatment centers and 1866 control sub…

AdultMaleOncologymedicine.medical_specialtyGenotypePoison controlSuicide AttemptedSingle-nucleotide polymorphismDopamine beta-HydroxylaseToxicologyPolymorphism Single NucleotideRisk AssessmentLinkage DisequilibriumGermanyInternal medicinemedicineHumansSNPPharmacology (medical)Age of OnsetDepression (differential diagnoses)PharmacologyDepressive DisorderSex CharacteristicsSuicide attemptAlcohol dependenceHaplotypeDNAMiddle AgedAlcoholismPsychiatry and Mental healthPhenotypeCase-Control StudiesSample SizeEtiologyFemalePsychologyGenome-Wide Association StudyClinical psychologyDrug and Alcohol Dependence
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PSYCHIATRY * P61 * DIMENSIONS AND CATEGORIES OF DSM V CRITERIA IN AN INTERNATIONAL SAMPLE OF DRINKING SUBJECTS AND INPATIENT ALCOHOL-DEPENDENT INDIVI…

2011

chemistry.chemical_compoundmedicine.medical_specialtychemistrymedicineAlcoholSample (statistics)General MedicinePsychiatryPsychologyClinical psychologyAlcohol and Alcoholism
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GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal

2005

N-Methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily, are generally inhibited by alcohol. The expression and alternative splicing of the obligatory NR1 subunit is altered by alcohol exposure, emphasizing the involvement of the NR1 subunit, which is coded by the GRIN1 gene, in alcohol-mediated effects. We performed an association study in patients with alcohol dependence with the GRIN1 locus. Two independent case control samples consisting of a total of 442 alcohol-dependent patients and 442 unrelated controls were included. There was no overall difference in allele or genotype frequency between patients and controls. However, the 2108A allele and A-co…

Geneticsmedicine.medical_specialtyDelirium tremensbiologyAlcohol dependenceGRIN1Locus (genetics)medicine.diseaseGenotype frequencyCellular and Molecular NeurosciencePsychiatry and Mental healthEpilepsyEndocrinologyInternal medicineGenotypemedicinebiology.proteinAlleleGenetics (clinical)American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
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