0000000000324292

AUTHOR

W.m. Wong

showing 1 related works from this author

No association of alcohol dependence with HOMER 1 and 2 genetic variants.

2010

Several lines of evidence indicate that alterations of the central cortico-accumbens glutamate pathway are involved in the development and maintenance of alcohol- and substance-use disorders. The HOMER protein family is encoded by 3 genes HOMER (1–3) which are components of the excitatory postsynaptic density complex and function to modulate synaptic activity by the regulation of glutamate signaling. HOMER 1 and 2 have been reported to contribute to chronic alcohol-induced long-term neurochemical changes in the endogenous reward system. Data from animal models suggest a potential role of the Homer protein family in the development of alcohol and substance use. The aim of this study is to as…

AdultMaleLinkage disequilibriumSingle-nucleotide polymorphismBiologyPolymorphism Single NucleotideLinkage DisequilibriumCellular and Molecular NeuroscienceGene FrequencyHomer Scaffolding ProteinsGenotypeGenetic variationSNPHumansGenetic Predisposition to DiseaseAlleleGenetics (clinical)GeneticsAlcohol dependenceHaplotypePsychiatry and Mental healthAlcoholismHaplotypesCase-Control StudiesFemaleCarrier ProteinsAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
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