0000000000324522
AUTHOR
Berthold Seitz
Hornhaut: endotheliale Dystrophien, endotheliale Degenerationen
Dieser Ubersichtsartikel bietet einen kurzen Uberblick uber die endothelialen Hornhautdystrophien (HD) und Degenerationen, deren primare Storung im Bereich des einschichtigen Endothels bzw. der Descemet-Membran liegt, sowie deren Therapie. Hornhautendotheldegenerationen sind definiert als Veranderungen des Endothels aufgrund von Alterungsprozessen oder durch Trauma (z. B. nach Kataraktchirurgie). Hornhautdystrophien beschreiben eine Vielzahl verschiedener erblicher Krankheitsbilder, bei denen meist ein bilateraler, nahezu ausschlieslicher Befall der Hornhaut vorliegt. Die Vererbung ist meist autosomal-dominant, kann aber auch autosomal-rezessiv und X-chromosomal-dominant sein.
Lattice Corneal Dystrophy Type 1
PURPOSE To evaluate the question whether lattice corneal dystrophy type 1 (LCD1) is of epithelial or stromal origin. METHODS The landmark of advanced LCD1 shows central superficial haze and paracentral stromal lattice lines. In 16 eyes of 8 affected individuals of 2 families, a penetrating keratoplasty was performed. The follow-up was 8 to 16 years after penetrating keratoplasty. Slit-lamp documentation of the patients was evaluated in direct and indirect illumination with dilated pupil to assess the horizontal and vertical pattern of new deposits on the corneal graft. Three affected patients of 2 families are demonstrated in detail. A DNA analysis was performed. RESULTS Gene identification…
SARS-CoV-2: Impact on, Risk Assessment and Countermeasures in German Eye Banks.
Introduction Since the beginning of the COVID-19 pandemic there has been some debate regarding the risk of transmission through tissue transplantation and tissue banking processes. Aim of the study To analyze the changes that SARS-CoV-2 has caused regarding the harvesting of corneal donor tissue and eye bank activities in Germany. Methods A questionnaire was provided to 26 eye banks in Germany, consisting of questions about adaptations made in the screening of potential donors and the harvesting of corneal tissue following the pandemic spread of SARS-CoV-2. Results Eighteen eye banks actively reduced recruitment of donors and two banks ceased all activity. Additional diagnostic screening wa…
IC3D Classification of Corneal Dystrophies—Edition 2
To update the 2008 International Classification of Corneal Dystrophies (IC3D) incorporating new clinical, histopathologic, and genetic information.The IC3D reviewed worldwide peer-reviewed articles for new information on corneal dystrophies published between 2008 and 2014. Using this information, corneal dystrophy templates and anatomic classification were updated. New clinical, histopathologic, and confocal photographs were added.On the basis of revisiting the cellular origin of corneal dystrophy, a modified anatomic classification is proposed consisting of (1) epithelial and subepithelial dystrophies, (2) epithelial-stromal TGFBI dystrophies, (3) stromal dystrophies, and (4) endothelial d…