0000000000324852

AUTHOR

María Brugada

showing 2 related works from this author

Human milk enhances antioxidant defenses against hydroxyl radical aggression in preterm infants

2008

Background: Preterm infants endowed with an immature antioxidant defense system are prone to oxidative stress. Hydroxyl radicals are very aggressive reactive oxygen species that lack specific antioxidants. These radicals cannot be measured directly, but oxidation byproducts of DNA or phenylalanine in urine are reliable markers of their activity. Human milk has a higher antioxidant capacity than formula. Objective: We hypothesized that oxidative stress associated with prematurity could be diminished by feeding human milk. Design: We recruited a cohort of stable preterm infants who lacked perinatal conditions associated with oxidative stress; were not receiving prooxidant or antioxidant drugs…

Malemedicine.medical_specialtyAntioxidantPhenylalaninemedicine.medical_treatmentMedicine (miscellaneous)Gestational AgePhenylalanineOxidative phosphorylationUrinemedicine.disease_causeAntioxidantsCohort StudiesTandem Mass SpectrometryInternal medicinemedicineHumansInfant Nutritional Physiological PhenomenaChromatography High Pressure Liquidchemistry.chemical_classificationAnalysis of VarianceReactive oxygen speciesNutrition and DieteticsMilk HumanHydroxyl RadicalInfant NewbornCase-control studyDeoxyguanosinemedicine.diseaseInfant FormulaOxidative StressEndocrinologychemistryBiochemistry8-Hydroxy-2'-DeoxyguanosinePremature birthCase-Control StudiesFemaleReactive Oxygen SpeciesBiomarkersInfant PrematureOxidative stressDNA DamageThe American Journal of Clinical Nutrition
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Antenatal Steroids and Antioxidant Enzyme Activity in Preterm Infants: Influence of Gender and Timing

2009

Antenatal steroids have improved the survival of preterm infants; however, the mechanism of action is not fully understood. We aimed to establish an association between antenatal steroids and antioxidant activity and postnatal oxidative stress. In a prospective cohort study, extremely preterm neonates receiving antenatal steroids (CORT) or not (NOCORT) were enrolled. An association between antenatal steroids and activities of antioxidant enzymes and glutathione cycle enzymes in cord blood was found. In addition, reduced oxidative stress (GSH/GSSG ratio, CORT vs. NOCORT, 35.68 + or - 12.20 vs. 28.38 + or - 9.92; p < 0.01) and, decreased oxidation of proteins (ortho-tyrosine/phenylalanine rat…

AdultMalemedicine.medical_specialtyAntioxidantAdolescentPhysiologymedicine.medical_treatmentClinical BiochemistryBiologymedicine.disease_causeBiochemistryAntioxidantsYoung Adultchemistry.chemical_compoundSex FactorsAdrenal Cortex HormonesPregnancyInternal medicinemedicineHumansProspective StudiesProspective cohort studyMolecular BiologyGeneral Environmental SciencePregnancySuperoxide DismutaseInfant NewbornRetinopathy of prematurityCell BiologyGlutathioneCatalasemedicine.diseaseOxidative StressEndocrinologyBronchopulmonary dysplasiachemistryCord bloodGeneral Earth and Planetary SciencesFemaleInfant PrematureOxidative stressAntioxidants &amp; Redox Signaling
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