0000000000326386

AUTHOR

Bastien Moindrot

showing 3 related works from this author

Upregulation of liver VLDL receptor and FAT/CD36 expressions in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid

2006

International audience; This study explores the mechanisms responsible for the fatty liver setup in mice fed trans-10,cis-12 conjugated linoleic acid (t10c12 CLA), hypothesizing that an induction of low density lipoprotein receptor (LDLR) expression is associated with lipid accumulation. To this end, the effects of t10c12 CLA treatment on lipid parameters, serum lipoproteins, and expression of liver lipid receptors were measured in LDLR(-/-) apoB(100/100) mice as a model of human familial hypercholesterolemia itself depleted of LDLR. Mice were fed t10c12 CLA over 2 or 4 weeks. We first observed that the treatment induced liver steatosis, even in the absence of LDLR. Mice treated for 2 weeks…

CD36 AntigensMaleVery low-density lipoproteinTRANSLOCASECD36RECEPTEUR SCAVENGER[SDV]Life Sciences [q-bio]FATTY ACID TRANSLOCASE030204 cardiovascular system & hematologyBiochemistryMice0302 clinical medicineEndocrinologyLinoleic Acids ConjugatedMice Knockout0303 health sciencesLipoprotein lipaselipoprotéinebiologyacide grasrécepteur d'hormoneChemistryFatty liverFatty Acidsfood and beveragesHEPATIC LIPASELipidsLOW DENSITY LIPOPROTEIN RECEPTOR3. Good healthUp-RegulationLiverSCAVENGER RECEPTOR CLASS B TYPE ILIVER STEATOSIS;LOW DENSITY LIPOPROTEIN RECEPTOR;TRIGLYCERIDE;LIPOATROPHY;LIPOPROTEIN;FATTY ACID TRANSLOCASE;VERY LOW DENSITY LIPOPROTEIN RECEPTOR;HEPATIC LIPASE;LIPOPROTEIN LIPASE;LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN;SCAVENGER RECEPTOR CLASS B TYPE I;LIPOATROPHIE;TRANSLOCASE;LIPASE HEPATIQUE;RECEPTEUR SCAVENGERApolipoprotein B-100lipoprotéine lipaseTRIGLYCERIDElipids (amino acids peptides and proteins)Oxidation-Reductionmedicine.medical_specialtyLIPASE HEPATIQUELipolysisVLDL receptorMice Transgenicacide linoléique conjugué03 medical and health sciencesstéatose hépatiqueInternal medicineLIVER STEATOSISmedicineLIPOPROTEIN LIPASEAnimalsRNA Messengerlipoprotéine de faible densite030304 developmental biologyLOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEINnutritional and metabolic diseasesCell Biologymedicine.diseaseLipid MetabolismLIPOATROPHYDietary FatsEndocrinologyLIPOPROTEINReceptors LDLVERY LOW DENSITY LIPOPROTEIN RECEPTORLIPOATROPHIELDL receptorbiology.proteinacide gras transHepatic lipaseLipoprotein
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Moderate consumption of beer reduces liver triglycerides and aortic cholesterol deposit in LDLr-/- apoB100/100 mice.

2006

This study was designed to address the effects of a moderate consumption of beer on serum and liver lipid parameters and on the development of aortic lesions in a mouse model associated with a human atherogenic lipoprotein profile. LDLr(-/-) apoB(100/100) mice received each day during 12 weeks either water, mild beer (0.570g of ethanol/kg of body weight) or ethanol-free beer in a single pure dose. Serum and liver lipid parameters were analyzed and atherosclerotic lesions were estimated in heart and aorta through their total cholesterol content. mRNA levels of enzymes and receptors involved in lipoprotein uptake, in fatty acid esterification and oxidation, and in reverse cholesterol transpor…

medicine.medical_specialtyApolipoprotein BAlcohol DrinkingCholesterol VLDLAortic DiseasesPalmitatesDown-RegulationAorta ThoracicMitochondria LiverPolymerase Chain ReactionPhosphatidylcholine-Sterol O-Acyltransferasechemistry.chemical_compoundMiceInternal medicinemedicineAnimalsRNA MessengerScavenger receptorChromatography High Pressure LiquidTriglyceridesApolipoproteins BbiologyTriglycerideCholesterolReverse cholesterol transportCholesterol HDLfood and beveragesBeerLipoprotein(a)Cholesterol LDLScavenger Receptors Class BAtherosclerosisMice Inbred C57BLEndocrinologychemistryLiverReceptors LDLLDL receptorbehavior and behavior mechanismsbiology.proteinlipids (amino acids peptides and proteins)FemaleCardiology and Cardiovascular MedicineOxidation-ReductionLipoproteinSterol Regulatory Element Binding Protein 2Atherosclerosis
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Regulation of lipid flux between liver and adipose tissue during transient hepatic steatosis in carnitine-depleted rats

2007

Rats with carnitine deficiency due to trimethylhydrazinium propionate (mildronate) administered at 80 mg/100 g body weight per day for 10 days developed liver steatosis only upon fasting. This study aimed to determine whether the transient steatosis resulted from triglyceride accumulation due to the amount of fatty acids preserved through impaired fatty acid oxidation and/or from up-regulation of lipid exchange between liver and adipose tissue. In liver, mildronate decreased the carnitine content by approximately 13-fold and, in fasted rats, lowered the palmitate oxidation rate by 50% in the perfused organ, increased 9-fold the triglyceride content, and doubled the hepatic very low density …

Malemedicine.medical_specialtyVery low-density lipoproteintissu adipeuxAdipose tissuerattus rattusBiochemistry03 medical and health scienceschemistry.chemical_compound0302 clinical medicinestéatose hépatiqueCarnitineInternal medicinemedicineAnimalsLipolysisCarnitineRats Wistarpathologie animaleMolecular BiologyBeta oxidationlipide030304 developmental biologychemistry.chemical_classification0303 health sciencesTriglycerideFatty AcidsFatty acidCell Biologyfoiemedicine.diseaseLipidsRats[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biomolecules [q-bio.BM]Fatty LiverLipoproteins LDLLipoprotein LipaseEndocrinologyAdipose TissueGene Expression RegulationLiverchemistryHepatocytesRATSteatosisTriolein030217 neurology & neurosurgerymedicine.drug
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