0000000000326609

AUTHOR

Rosanna Avola

showing 2 related works from this author

Chamazulene-Rich Artemisia arborescens Essential Oils Affect the Cell Growth of Human Melanoma Cells

2020

Artemisia arborescens is an aromatic shrub whose essential oils are considered a potential source of molecules with industrial and pharmaceutical interest. The chemical profile of A. arborescens essential oils (EOs) was shown to be quite variable and various chemotypes have been identified. In this study, we compared the EOs composition of A. arborescens leaves and flowers collected from four different locations in Sicily. The EOs were assayed for their antiproliferative activity against A375 human malignant melanoma cells, also testing cell viability and cell membrane integrity. The evaluation of DNA fragmentation and caspase-3 activity assay was employed for the detection of apoptosis. Th…

antiproliferative activitymelanoma cancer cellArtemisia arborescensPlant ScienceArticleessential oillaw.inventionSuperoxide dismutase03 medical and health scienceschemistry.chemical_compound0302 clinical medicinemelanoma cancer cellslawcamphor<i>Artemisia arborescens</i>Viability assayEcology Evolution Behavior and SystematicsEssential oil030304 developmental biology0303 health sciencesEcologybiologyChemistryCell growthChamazuleneBotanychamazuleneArtemisia arborescensbiology.organism_classificationBiochemistryApoptosis030220 oncology & carcinogenesisQK1-989Artemisia arborescenbiology.proteinDNA fragmentationPlants
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Involvement of Bax and Bcl-2 in induction of apoptosis by essential oils of three Lebanese Salvia species in human prostate cancer cells

2018

Prostate cancer is one of the most common forms of cancer in men, and research to find more effective and less toxic drugs has become necessary. In the frame of our ongoing program on traditionally used Salvia species from the Mediterranean Area, here we report the biological activities of Salvia aurea, S. judaica and S. viscosa essential oils against human prostate cancer cells (DU-145). The cell viability was measured by 3(4,5-dimethyl-thiazol-2-yl)2,5-diphenyl-tetrazolium bromide (MTT) test and lactate dehydrogenase (LDH) release was used to quantify necrosis cell death. Genomic DNA, caspase-3 activity, expression of cleaved caspase-9, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X (Ba…

Male0301 basic medicineSalvia miltiorrhiza<i>Salvia</i>; essential oil; prostate cancer; apoptosis; reactive oxygen specieslcsh:ChemistryProstate cancer0302 clinical medicineSalvialcsh:QH301-705.5Spectroscopybcl-2-Associated X Proteinreactive oxygen speciesCamphanesapoptosisGeneral Medicineprostate cancerComputer Science ApplicationsGene Expression Regulation NeoplasticProto-Oncogene Proteins c-bcl-2030220 oncology & carcinogenesisApoptosis Essential oil Prostate cancer Reactive oxygen species SalviaProgrammed cell deathSalvia; apoptosis; essential oil; prostate cancer; reactive oxygen speciesPanax notoginsengDNA FragmentationBiologyArticleCatalysisessential oilInorganic Chemistry03 medical and health sciencesBcl-2-associated X proteinCell Line TumorOils VolatilemedicineHumansViability assayPhysical and Theoretical ChemistryMolecular BiologyCell ProliferationCell growthOrganic ChemistryProstatic NeoplasmsCancerSettore CHIM/06 - Chimica Organicamedicine.diseaseapoptosi030104 developmental biologylcsh:Biology (General)lcsh:QD1-999ApoptosisCancer cellCancer researchbiology.proteinDrugs Chinese Herbal
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