0000000000326779

AUTHOR

Alexandra P. Lam

showing 3 related works from this author

Long-term improvement of quality of life in adult ADHD – results of the randomized multimodal COMPAS trial

2021

Attention Deficit Hyperactivity Disorder (ADHD) negatively impacts Quality of Life (QoL) in adults. Earlier studies on pharmacological treatment have shown short-term beneficial effects on QoL. No data are available on long-term effects on multimodal psychosocial and/or pharmacological interventions. The Comparison of Methylphenidate and Psychotherapy in Adult ADHD Study (COMPAS), a prospective, multicenter randomized clinical trial, compared cognitive behavioral group psychotherapy (GPT) with individual clinical management (CM) and methylphenidate (MPH) with placebo (Plac) (2 × 2 factorial design over a period of 52 weeks). Change of QoL was measured after three months of intensive treatme…

medicine.medical_specialtybusiness.industryMethylphenidateHealth PolicyMedizinPublic Health Environmental and Occupational Healthmedicine.diseasehumanities030227 psychiatry3. Good healthPharmacological treatmentTerm (time)03 medical and health sciencesPsychiatry and Mental health0302 clinical medicineQuality of lifemedicineAttention deficit hyperactivity disorderPsychiatrybusinessBeneficial effects030217 neurology & neurosurgerymedicine.drugInternational Journal of Mental Health
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Long-term Effects of Multimodal Treatment on Adult Attention-Deficit/Hyperactivity Disorder Symptoms: Follow-up Analysis of the COMPAS Trial.

2019

Key Points Question What are the long-term results of multimodal treatment for adult attention-deficit/hyperactivity disorder (ADHD) when comparing cognitive behavioral group psychotherapy (GPT) with individual clinical management (CM) in combination with either methylphenidate or placebo? Findings In this follow-up assessment of the Comparison of Methylphenidate and Psychotherapy in Adult ADHD Study (COMPAS), a multicenter randomized clinical trial, 256 adults participated in follow-up 1.5 years after the intervention ended. The severity of ADHD symptoms improved in all 4 prior treatment groups, with no significant difference found between GPT and CM, but methylphenidate was associated wit…

AdultMalemedicine.medical_specialtyRandomizationMedizinPlacebolaw.invention03 medical and health sciencesYoung Adult0302 clinical medicineRandomized controlled triallawRating scalemental disordersmedicineAttention deficit hyperactivity disorderHumansYoung adultOriginal InvestigationPsychiatryCognitive Behavioral Therapybusiness.industryResearchBeck Depression InventoryGeneral MedicineMiddle Aged16. Peace & justicemedicine.diseaseCombined Modality Therapy030227 psychiatry3. Good healthOnline OnlyTreatment OutcomeAttention Deficit Disorder with HyperactivityPhysical therapyClinical Global ImpressionMethylphenidateCentral Nervous System StimulantsFemalebusiness030217 neurology & neurosurgeryFollow-Up StudiesJAMA network open
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Effectiveness of Psychotherapy in Adult ADHD: What Do Patients Think? Results of the COMPAS Study

2017

Objective: In the multicenter study Comparison of Methylphenidate and Psychotherapy in Adult ADHD (COMPAS), the efficacy of treatments has been primarily evaluated by observer-rated symptom change. Here, we additionally analyzed the patients’ subjective evaluation of therapy effects. Method: COMPAS compared ADHD-specific group therapy with unspecific clinical management with/without concomitant pharmacotherapy in a four-armed design. Evaluation through the patients’ retrospective perspective was performed after 1 year (post-treatment) and after another 1.5 years (follow-up). Results: In respect to patients’ subjective ratings, ADHD-specific group psychotherapy outperformed unspecific manage…

AdultMindfulnessPsychotherapistmedicine.medical_treatmentMedizinGroup psychotherapy03 medical and health sciences0302 clinical medicinePharmacotherapyDevelopmental and Educational PsychologymedicineHumans0501 psychology and cognitive sciencesRetrospective StudiesTherapy EvaluationMethylphenidate05 social sciences3. Good healthClinical PsychologyTreatment OutcomeMulticenter studyAttention Deficit Disorder with HyperactivityConcomitantMethylphenidatePsychotherapy GroupCentral Nervous System StimulantsPsychology030217 neurology & neurosurgery050104 developmental & child psychologyClinical psychologymedicine.drug
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