Long-term Effects of Multimodal Treatment on Adult Attention-Deficit/Hyperactivity Disorder Symptoms: Follow-up Analysis of the COMPAS Trial.

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RESEARCH PRODUCT

Long-term Effects of Multimodal Treatment on Adult Attention-Deficit/Hyperactivity Disorder Symptoms: Follow-up Analysis of the COMPAS Trial.

Michael Colla Mathias Berger Michael Huss Bernhard Kis Swantje Matthies Michael Rösler Erika Graf Thomas Jans Wolfgang Retz Wolfgang Retz Christian Jacob Barbara Alm Helge H. O. Müller Ludger Tebartz Van Elst Alexandra P. Lam Alexandra Philipsen Caroline Lücke Mona Abdel-hamid Esther Sobanski Petra Retz-junginger

subject

Adult Male medicine.medical_specialty Randomization Medizin Placebo law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Randomized controlled trial law Rating scale mental disorders medicine Attention deficit hyperactivity disorder Humans Young adult Original Investigation Psychiatry Cognitive Behavioral Therapy business.industry Research Beck Depression Inventory General Medicine Middle Aged 16. Peace & justice medicine.disease Combined Modality Therapy 030227 psychiatry 3. Good health Online Only Treatment Outcome Attention Deficit Disorder with Hyperactivity Physical therapy Clinical Global Impression Methylphenidate Central Nervous System Stimulants Female business 030217 neurology & neurosurgery Follow-Up Studies

description

Key Points Question What are the long-term results of multimodal treatment for adult attention-deficit/hyperactivity disorder (ADHD) when comparing cognitive behavioral group psychotherapy (GPT) with individual clinical management (CM) in combination with either methylphenidate or placebo? Findings In this follow-up assessment of the Comparison of Methylphenidate and Psychotherapy in Adult ADHD Study (COMPAS), a multicenter randomized clinical trial, 256 adults participated in follow-up 1.5 years after the intervention ended. The severity of ADHD symptoms improved in all 4 prior treatment groups, with no significant difference found between GPT and CM, but methylphenidate was associated with a larger improvement in symptoms compared with placebo. Meaning Results from the COMPAS trial demonstrate an improvement of ADHD symptoms over 1.5 years in adults with ADHD after 1 year of treatment with methylphenidate plus either GPT or CM.

year	journal	country	edition	language
2019-06-01	JAMA network open

10.1001/jamanetworkopen.2019.4980 https://pubmed.ncbi.nlm.nih.gov/31150084