0000000000326951

AUTHOR

Julianna Kele

0000-0003-3418-1412

showing 1 related works from this author

Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth

2010

Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases. However, the molecular mechanisms through which NGF regulates cytoskeletal changes and neurite outgrowth are not totally understood. In this work, we identify the Rac1-specific guanine exchange factor (GEF) Tiam1 as a novel mediator of NGF/TrkA-dependent neurite elongation. In particular, we report that knockdown of Tiam1 causes a significant reduction in Rac1 activity and neurite outgrowth induced by NGF. Physical interaction between Tiam1 and active Ras (Ras- GTP), but not tyrosine phosphorylation of Tiam1, plays a central role in Rac1 activation by NGF. In add…

rac1 GTP-Binding ProteinTiam1; Nerve growth factor (NGF)GTPaseTropomyosin receptor kinase ABiochemistryPC12 CellsCell Biology/Cell Signalingchemistry.chemical_compoundChlorocebus aethiopsNerve Growth FactorTiam1Guanine Nucleotide Exchange FactorsT-Lymphoma Invasion and Metastasis-inducing Protein 1NGFNeuronsMultidisciplinaryUNESCO::CIENCIAS DE LA VIDA::Biología molecularQOtras Medicina BásicaRCell Differentiation//purl.org/becyt/ford/3.1 [https]Cell biologyNeoplasm ProteinsMedicina BásicaNeuronal differentiationNerve growth factor (NGF)COS CellsMedicine//purl.org/becyt/ford/3 [https]Guanine nucleotide exchange factorSignal transductionResearch ArticleSignal TransductionCIENCIAS MÉDICAS Y DE LA SALUDNeuriteScienceCell Biology/Neuronal Signaling MechanismsRAC1Biology:CIENCIAS DE LA VIDA::Biología molecular [UNESCO]Neuroscience/Neuronal Signaling MechanismsNeuritesAnimalsHumansReceptor trkATyrosine phosphorylationMolecular biologyRatsNerve growth factorchemistrynervous systemras ProteinsRac1 GTPasePLoS ONE
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