Stato nutrizionale e citochine nell’insufficienza renale cronica

Relationship of fetuin-A with glomerular filtration rate and endothelial dysfunction in moderate-severe chronic kidney disease

Background: In end-stage renal disease, fetuin-A has been demonstrated to be reduced and inversely related to cardiovascular mortality. This study had 2 distinct aims. The first was to verify if circulating concentration of fetuin-A may depend on renal function in patients with chronic kidney disease (CKD). Furthermore, we analyzed the correlation of fetuin-A with the biomarker of endothelial dysfunction endothelin-1 (ET-1), and with the inflammatory cytokine interleukin-6 (IL-6). Methods: In 108 subjects with stage 3-5 CKD, plasma levels of fetuin-A, ET-1 and IL-6 were assayed. Patients were studied first as a whole group and then were divided according to stages of CKD and fetuin-A tertil…

Nutritional status and endothelial factors in chronic renal failure

Oxidative stress, inflammation and cardiovascular disease in chronic renal failure

Traditional risk factors such as hypertension, diabetes, dyslipidemia, obesity and metabolic syndrome, as well as additional nontraditional risk factors, can damage the kidney directly and by promoting intrarenal atherogenesis. Evidence indicates that increased oxidative stress and inflammation may mediate most of the effects of risk factors on the kidney. Clinical studies have demonstrated a relationship between oxidative stress and inflammatory biomarkers, and a few studies indicate an inverse correlation of oxidative stress biomarkers with estimated glomerular filtration rate (eGFR). Further, surrogate indexes of atherosclerosis such as intima-media thickness and aortic pulse wave veloci…

Pregnancy in advanced maternal age: maternal and fetal outcome.

The objective of this research is to evaluate maternal and fetal outcome of pregnant women over 40 years. The outcome has been evaluated through the following data: age, nationality, number of deliveries, complications of pregnancy, type of delivery, newborn's weight and APGAR index. 201 pregnant women have been recruited. The GDM has been observed in 11 women (5.5%). The antepartum haemorrhage has been observed in 7 women (3.5%). The cesarean section rate was 76% in the Group of primiparae woman and 64% in the Group of multiparae. The incidence of Children LBW (low Birth weight) was 17% in the primiparae and 10% in the multiparare.