0000000000327886

AUTHOR

Krassler J.

showing 4 related works from this author

Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protoc…

2019

Background: Postoperative pulmonary complications (PPC) may result in longer duration of in-hospital stay and even mortality. Both thoracic surgery and intraoperative mechanical ventilation settings add considerably to the risk of PPC. It is unclear if one-lung ventilation (OLV) for thoracic surgery with a strategy of intraoperative high positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM) reduces PPC, compared to low PEEP without RM. Methods: PROTHOR is an international, multicenter, randomized, controlled, assessor-blinded, two-arm trial initiated by investigators of the PROtective VEntilation NETwork. In total, 2378 patients will be randomly assigned to one of two diffe…

one-lung ventilationIntraoperative ComplicationMedicine (miscellaneous)Thoracic Surgical Procedurerecruitment maneuverOrvostudományokrespiratory systemThoracic Surgical ProceduresKlinikai orvostudományokthoracic surgeryrespiratory tract diseasesPositive-Pressure RespirationMechanical ventilation; one-lung ventilation; positive end-expiratory pressure; postoperative pulmonary complication; recruitment maneuver; thoracic surgery; Humans; Intraoperative Complications; One-Lung Ventilation; Positive-Pressure Respiration; Research Design; Sample Size; Thoracic Surgical Procedures; Randomized Controlled Trials as TopicMechanical ventilationResearch DesignSample SizeHumansPharmacology (medical)postoperative pulmonary complicationIntraoperative ComplicationsMechanical ventilation; one-lung ventilation; positive end-expiratory pressure; postoperative pulmonary complication; recruitment maneuver; thoracic surgery; Medicine (miscellaneous); Pharmacology (medical)Humanpositive end-expiratory pressureRandomized Controlled Trials as Topic
researchProduct

Correction to: Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR…

2019

After publication of the original article [1], the authors have notified us that two of the collaborator first and last names have been inverted in the "PROTHOR Investigators" table. The correct information is: Surname: Spadaro Name: Savino Surname Vitali Name Costanza The original article has been corrected.

protective ventilationMedicine (miscellaneous)Medicine (miscellaneous); Pharmacology (medical)Pharmacology (medical)
researchProduct

Death in hospital following ICU discharge: insights from the LUNG SAFE study

2021

Abstract Background To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments (‘treatment limitations’), and the subpopulations with tre…

MaleARDSLUNG SAFEhealth care facilities manpower and servicesAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Hospital survival; ICU discharge; LUNG SAFEKaplan-Meier EstimateCritical Care and Intensive Care MedicineAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Hospital survival; ICU discharge; LUNG SAFE;0302 clinical medicineRisk Factors030212 general & internal medicineProspective StudiesProspective cohort studyAcute hypoxemic respiratory failureCOPDAcute respiratory distress syndromeICU dischargeMedical emergencies. Critical care. Intensive care. First aidMiddle AgedPatient DischargeLUNG SAFE.Intensive Care Unitsmedicine.anatomical_structureLung safeSOFA scoreFemaleRespiratory InsufficiencyAdultmedicine.medical_specialtyNOHospital survival03 medical and health sciencesSettore MED/41 - ANESTESIOLOGIAmedicineHumansddc:610Risk factorMortalityAgedLungRC86-88.9business.industryResearch030208 emergency & critical care medicinemedicine.diseaseLogistic Modelslnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]Respiratory failureEmergency medicineObservational studybusiness
researchProduct

Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: Post-hoc analysis of L…

2020

Abstract Background Limited information is available regarding intraoperative ventilator settings and the incidence of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgical procedures. The aim of this post-hoc analysis of the ‘Multicentre Local ASsessment of VEntilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) study was to examine the ventilator settings of patients undergoing neurosurgical procedures, and to explore the association between perioperative variables and the development of PPCs in neurosurgical patients. Methods Post-hoc analysis of LAS VEGAS study, restricted to patients undergoing neurosurgery. Patients were stratified into g…

Lung DiseasesMaleSURGERYmedicine.medical_treatment[SDV]Life Sciences [q-bio]RESPIRATORY-DISTRESS-SYNDROMEBRAIN-INJURYNeurosurgical ProceduresPositive-Pressure Respiration0302 clinical medicinePostoperative ComplicationsMechanical ventilation030202 anesthesiologyInterquartile rangeMedicine and Health SciencesGeneral anaesthesiaEND-EXPIRATORY-PRESSUREProspective StudiesPostoperative pulmonaryPostoperative pulmonary complicationsMiddle Aged3. Good health[SDV] Life Sciences [q-bio]AnesthesiaFemaleNeurosurgeryResearch ArticlePulmons MalaltiesAdultmedicine.medical_specialtycomplicationsNeurosurgeryLung injuryAnesthesia GeneralLAS VEGAS; Mechanical ventilation; Neurosurgery; Postoperative pulmonary complications;NOlcsh:RD78.3-87.3LAS VEGAS ; Mechanical ventilation ; Neurosurgery ; Postoperative pulmonary complications.03 medical and health sciencesNeurologiaLAS VEGASAnesthesiologymedicineTidal VolumeHumansMED/41 - ANESTESIOLOGIAHIGH TIDALAgedMechanical ventilationIntraoperative CareVentilators MechanicalCirurgiabusiness.industry030208 emergency & critical care medicineOdds ratioPerioperativeRespiration ArtificialAnesthesiology and Pain Medicinelcsh:AnesthesiologyVOLUMELAS VEGAS; Mechanical ventilation; Neurosurgery; Postoperative pulmonary complicationsbusinessPostoperative pulmonary complicationLUNG INJURY
researchProduct