6533b871fe1ef96bd12d25bd

RESEARCH PRODUCT

Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: Post-hoc analysis of LAS VEGAS study

Robba C.Hemmes S. N. T.Serpa Neto A.Bluth T.Canet J.Hiesmayr M.Hollmann M. W.Mills G. H.Vidal Melo M. F.Putensen C.Jaber S.Schmid W.Severgnini P.Wrigge H.Battaglini D.Ball L.Gama De Abreu M.Schultz M. J.Pelosi P.Kroell W.Metzler H.Struber G.Wegscheider T.Gombotz H.Hiesmayr M.Schmid W.Urbanek B.Kahn D.Momeni M.Pospiech A.Lois F.Forget P.Grosu I.Poelaert J.Van Mossevelde V.Van Malderen M. -C.Dylst D.Van Melkebeek J.Beran M.De Hert S.De Baerdemaeker L.Heyse B.Van Limmen J.Wyffels P.Jacobs T.Roels N.De Bruyne A.Van De Velde S.Leva B.Damster S.Plichon B.Juros-zovko M.Djonovic-omanovic D.Pernar S.Zunic J.Miskovic P.Zilic A.Kvolik S.Ivic D.Azenic-venzera D.Skiljic S.Vinkovic H.Oputric I.Juricic K.Frkovic V.Kopic J.Mirkovic I.Karanovic N.Carev M.Dropulic N.Saric J. P.Erceg G.Dvorscak M. B.Mazul-sunko B.Pavicic A. M.Goranovic T.Maldini B.Radocaj T.Gavranovic Z.Mladic-batinica I.Sehovic M.Stourac P.Harazim H.Smekalova O.Kosinova M.Kolacek T.Hudacek K.Drab M.Brujevic J.Vitkova K.Jirmanova K.Volfova I.Dzurnakova P.Liskova K.Dudas R.Filipsky R.El Kafrawy S.Abdelwahab H. H.Metwally T.Abdel-razek A.El-shaarawy A. M.Hasan W. F.Ahmed A. G.Yassin H.Magdy M.Abdelhady M.Mahran M.Herodes E.Kivik P.Oganjan J.Aun A.Sormus A.Sarapuu K.Mall M.Karjagin J.Futier E.Petit A.Gerard A.Marret E.Solier M.Jaber S.Prades A.Krassler J.Merzky S.De Abreu M. G.Uhlig C.Kiss T.Bundy A.Bluth T.Gueldner A.Spieth P.Scharffenberg M.Thiem D. T.Koch T.Treschan T.Schaefer M.Bastin B.Geib J.Weiss M.Kienbaum P.Pannen B.Gottschalk A.Konrad M.Westerheide D.Schwerdtfeger B.Wrigge H.Simon P.Reske A.Nestler C.Valsamidis D.Stroumpoulis K.Antholopoulos G.Andreou A.Karapanos D.Theodoraki K.Gkiokas G.Tasoulis M. -K.Sidiropoulou T.Zafeiropoulou F.Florou P.Pandazi A.Tsaousi G.Nouris C.Pourzitaki C.Bystritski D.Pizov R.Eden A.Pesce C. V.Campanile A.Marrella A.Grasso S.De Michele M.Bona F.Giacoletto G.Sardo E.Giancarlo L.Sottosanti V.Solca M.Volta C. A.Spadaro S.Verri M.Ragazzi R.Zoppellari R.Cinnella G.Raimondo P.La Bella D.Mirabella L.D'antini D.Pelosi P.Molin A.Brunetti I.Gratarola A.Pellerano G.Sileo R.Pezzatto S.Montagnani L.Pasin L.Landoni G.Zangrillo A.Beretta L.Di Parma A. L.Tarzia V.Dossi R.Sassone M. E.Sances D.Tredici S.Spano G.Castellani G.Delunas L.Peradze S.Venturino M.Arpino I.Sher S.Tommasino C.Rapido F.Morelli P.Vargas M.Servillo G.Cortegiani A.Raineri S. M.Montalto F.Russotto V.Giarratano A.Baciarello M.Generali M.Cerati G.Leykin Y.Bressan F.Bartolini V.Zamidei L.Brazzi L.Liperi C.Sales G.Pistidda L.Severgnini P.Brugnoni E.Musella G.Bacuzzi A.Muhardri D.Gecaj-gashi A.Sada F.Bytyqi A.Karbonskiene A.Aukstakalniene R.Teberaite Z.Salciute E.Tikuisis R.Miliauskas P.Jurate S.Kontrimaviciute E.Tomkute G.Xuereb J.Bezzina M.Borg F. J.Hemmes S.Schultz M.Hollmann M.Wiersma I.Binnekade J.Bos L.Boer C.Duvekot A.In 'T Veld B.Werger A.Dennesen P.Severijns C.De Jong J.Hering J.Van Beek R.Ivars S.Jammer I.Breidablik A.Hodt K. S.Fjellanger F.Avalos M. V.Mellin-olsen J.Andersson E.Shafi-kabiri A.Molina R.Wutai S.Morais E.Tareco G.Ferreira D.Amaral J.De Lurdes Goncalves Castro M.Cadilha S.Appleton S.Parente S.Correia M.Martins D.Monteirosa A.Ricardo A.Rodrigues S.Horhota L.Grintescu I. M.Mirea L.Grintescu I. C.Corneci D.Negoita S.Dutu M.Garotescu I. P.Filipescu D.Prodan A. B.Droc G.Fota R.Popescu M.Tomescu D.Petcu A. M.Tudoroiu M. I.Moise A.Guran C. -T.Gherghina I.Costea D.Cindea I.Copotoiu S. -M.Copotoiu R.Barsan V.Tolcser Z.Riciu M.Moldovan S. G.Veres M.Gritsan A.Kapkan T.Gritsan G.Korolkov O.Kulikov A.Lubnin A.Ovezov A.Prokoshev P.Lugovoy A.Anipchenko N.Babayants A.Komissarova I.Zalina K.Likhvantsev V.Fedorov S.Lazukic A.Pejakovic J.Mihajlovic D.Kusnierikova Z.Zelinkova M.Bruncakova K.Polakovicova L.Sobona V.Novak-supe B.Pekle-golez A.Jovanov M.Strazisar B.Markovic-bozic J.Novak-jankovic V.Voje M.Grynyuk A.Kostadinov I.Spindler-vesel A.Moral V.Unzueta M. C.Puigbo C.Fava J.Canet J.Moret E.Nunez M. R.Sendra M.Brunelli A.Rodenas F.Monedero P.Martinez F. H.Temino M. J. Y.Simon A. M.De Abajo Larriba A.Lisi A.Perez G.Martinez R.Granell M.Vivo J. T.Ruiz C. S.De Andres Ibanez J. A.Pastor E.Soro M.Ferrando C.Defez M.Alvares-santullano C. A.Perez R.Rico J.Jawad M.Saeed Y.Gillberg L.Bengisun Z. K.Kazbek B. K.Coskunfirat N.Boztug N.Sanli S.Yilmaz M.Hadimioglu N.Senturk N. M.Camci E.Kucukgoncu S.Sungur Z.Sivrikoz N.Ozgen S. U.Toraman F.Selvi O.Senturk O.Yildiz M.Kuvaki B.Gunenc F.Kucukguclu S.Ozbilgin S.Maral J.Canli S.Arun O.Saltali A.Aydogan E.Akgun F. N.Sanlikarip C.Karaman F. M.Mazur A.Vorotyntsev S.Rousseau G.Barrett C.Stancombe L.Shelley B.Scholes H.Limb J.Rafi A.Wayman L.Deane J.Rogerson D.Williams J.Yates S.Rogers E.Pulletz M.Moreton S.Jones S.Venkatesh S.Burton M.Brown L.Goodall C.Rucklidge M.Fuller D.Nadolski M.Kusre S.Lundberg M.Everett L.Nutt H.Zuleika M.Carvalho P.Clements D.Creagh-brown B.Watt P.Raymode P.Pearse R.Mohr O.Raj A.Creary T.Chishti A.Bell A.Higham C.Cain A.Gibb S.Mowat S.Franklin D.West C.Minto G.Boyd N.Mills G.Calton E.Walker R.Mackenzie F.Ellison B.Roberts H.Chikungwa M.Jackson C.Donovan A.Foot J.Homan E.Montgomery J.Portch D.Mercer P.Palmer J.Paddle J.Fouracres A.Datson A.Andrew A.Welch L.Rose A.Varma S.Simeson K.Rambhatla M.Susarla J.Marri S.Kodaganallur K.Das A.Algarsamy S.Colley J.Davies S.Szewczyk M.Smith T.Fernandez-bustamante A.Luzier E.Almagro A.Melo M. V.Fernando L.Sulemanji D.Sprung J.Weingarten T.Kor D.Scavonetto F.Tze Y.

subject

Lung DiseasesMaleSURGERYmedicine.medical_treatment[SDV]Life Sciences [q-bio]RESPIRATORY-DISTRESS-SYNDROMEBRAIN-INJURYNeurosurgical ProceduresPositive-Pressure Respiration0302 clinical medicinePostoperative ComplicationsMechanical ventilation030202 anesthesiologyInterquartile rangeMedicine and Health SciencesGeneral anaesthesiaEND-EXPIRATORY-PRESSUREProspective StudiesPostoperative pulmonaryPostoperative pulmonary complicationsMiddle Aged3. Good health[SDV] Life Sciences [q-bio]AnesthesiaFemaleNeurosurgeryResearch ArticlePulmons MalaltiesAdultmedicine.medical_specialtycomplicationsNeurosurgeryLung injuryAnesthesia GeneralLAS VEGAS; Mechanical ventilation; Neurosurgery; Postoperative pulmonary complications;NOlcsh:RD78.3-87.3LAS VEGAS ; Mechanical ventilation ; Neurosurgery ; Postoperative pulmonary complications.03 medical and health sciencesNeurologiaLAS VEGASAnesthesiologymedicineTidal VolumeHumansMED/41 - ANESTESIOLOGIAHIGH TIDALAgedMechanical ventilationIntraoperative CareVentilators MechanicalCirurgiabusiness.industry030208 emergency & critical care medicineOdds ratioPerioperativeRespiration ArtificialAnesthesiology and Pain Medicinelcsh:AnesthesiologyVOLUMELAS VEGAS; Mechanical ventilation; Neurosurgery; Postoperative pulmonary complicationsbusinessPostoperative pulmonary complicationLUNG INJURY

description

Abstract Background Limited information is available regarding intraoperative ventilator settings and the incidence of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgical procedures. The aim of this post-hoc analysis of the ‘Multicentre Local ASsessment of VEntilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) study was to examine the ventilator settings of patients undergoing neurosurgical procedures, and to explore the association between perioperative variables and the development of PPCs in neurosurgical patients. Methods Post-hoc analysis of LAS VEGAS study, restricted to patients undergoing neurosurgery. Patients were stratified into groups based on the type of surgery (brain and spine), the occurrence of PPCs and the assess respiratory risk in surgical patients in Catalonia (ARISCAT) score risk for PPCs. Results Seven hundred eighty-four patients were included in the analysis; 408 patients (52%) underwent spine surgery and 376 patients (48%) brain surgery. Median tidal volume (VT) was 8 ml [Interquartile Range, IQR = 7.3–9] per predicted body weight; median positive end–expiratory pressure (PEEP) was 5 [3 to 5] cmH20. Planned recruitment manoeuvres were used in the 6.9% of patients. No differences in ventilator settings were found among the sub-groups. PPCs occurred in 81 patients (10.3%). Duration of anaesthesia (odds ratio, 1.295 [95% confidence interval 1.067 to 1.572]; p = 0.009) and higher age for the brain group (odds ratio, 0.000 [0.000 to 0.189]; p = 0.031), but not intraoperative ventilator settings were independently associated with development of PPCs. Conclusions Neurosurgical patients are ventilated with low VT and low PEEP, while recruitment manoeuvres are seldom applied. Intraoperative ventilator settings are not associated with PPCs.

yearjournalcountryeditionlanguage
2020-04-02
10.1186/s12871-020-00988-x