0000000000123533

AUTHOR

Cortegiani A.

showing 10 related works from this author

Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit

2018

PURPOSE: To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU. METHODS: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up. RESULTS: LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withholding decision and 12.2% a withdrawal decision (including those with a previous withholding decision). Patients with LST limitation were older, more frail, more severely ill and less frequently electively admitted. Patients with withdrawal of LST were more frequently male and had a longer ICU len…

Malemedicine.medical_treatmentHSJ UCICritical Care and Intensive Care Medicinelaw.inventionLife sustaining treatment0302 clinical medicineElderlylaw80 and overMedicine030212 general & internal medicineProspective StudiesProspective cohort studyAged 80 and overeducation.field_of_studyWithholding Treatmentddc:617[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontologyWithholdingIntensive care unit3. Good healthEuropeagedIntensive Care UnitsWithdrawalSOFA scoreHumanmedicine.medical_specialtyethical aspectsPopulationIntensive Care UnitDecision MakingElderly; Ethics; Intensive care; Life sustaining treatment; Withdrawal; Withholding;life-sustaining therapyNO03 medical and health sciencesIntensive careAnesthesiologyHumansEthiceducationMechanical ventilationEthicsbusiness.industry030208 emergency & critical care medicineElderly; Ethics; Intensive care; Life sustaining treatment; Withdrawal; Withholdingcritical careLife Support CareProspective StudieWithholding TreatmentIntensive careEmergency medicineElderly; Ethics; Intensive care; Life sustaining treatment; Withdrawal; Withholding; Aged 80 and over; Decision Making; Europe; Humans; Intensive Care Units; Male; Prospective Studies; Life Support Care; Withholding Treatmentbusiness
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Sigh in patients with acute hypoxemic respiratory failure and acute respiratory distress syndrome: the PROTECTION pilot randomized clinical trial

2021

Background: Sigh is a cyclic brief recruitment manoeuvre: previous physiological studies showed that its use could be an interesting addition to pressure support ventilation to improve lung elastance, decrease regional heterogeneity and increase release of surfactant. Research question: Is the clinical application of sigh during pressure support ventilation (PSV) feasible? Study design and methods: We conducted a multi-center non-inferiority randomized clinical trial on adult intubated patients with acute hypoxemic respiratory failure or acute respiratory distress syndrome undergoing PSV. Patients were randomized to the No Sigh group and treated by PSV alone, or to the Sigh group, treated b…

pressure supportventilationsighARDSmechanical ventilationfeasibility
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Death in hospital following ICU discharge: insights from the LUNG SAFE study

2021

Abstract Background To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments (‘treatment limitations’), and the subpopulations with tre…

MaleARDSLUNG SAFEhealth care facilities manpower and servicesAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Hospital survival; ICU discharge; LUNG SAFEKaplan-Meier EstimateCritical Care and Intensive Care MedicineAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Hospital survival; ICU discharge; LUNG SAFE;0302 clinical medicineRisk Factors030212 general & internal medicineProspective StudiesProspective cohort studyAcute hypoxemic respiratory failureCOPDAcute respiratory distress syndromeICU dischargeMedical emergencies. Critical care. Intensive care. First aidMiddle AgedPatient DischargeLUNG SAFE.Intensive Care Unitsmedicine.anatomical_structureLung safeSOFA scoreFemaleRespiratory InsufficiencyAdultmedicine.medical_specialtyNOHospital survival03 medical and health sciencesSettore MED/41 - ANESTESIOLOGIAmedicineHumansddc:610Risk factorMortalityAgedLungRC86-88.9business.industryResearch030208 emergency & critical care medicinemedicine.diseaseLogistic Modelslnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]Respiratory failureEmergency medicineObservational studybusiness
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Cumulative Prognostic Score Predicting Mortality in Patients Older Than 80 Years Admitted to the ICU

2019

OBJECTIVES To develop a scoring system model that predicts mortality within 30 days of admission of patients older than 80 years admitted to intensive care units (ICUs). DESIGN Prospective cohort study. SETTING A total of 306 ICUs from 24 European countries. PARTICIPANTS Older adults admitted to European ICUs (N = 3730; median age = 84 years [interquartile range = 81‐87 y]; 51.8% male). MEASUREMENTS Overall, 24 variables available during ICU admission were included as potential predictive variables. Multivariable logistic regression was used to identify independent predictors of 30‐day mortality. Model sensitivity, specificity, and accuracy were evaluated with receiver operating characteris…

MaleINTENSIVE-CARE-UNITOrgan Dysfunction Scoresmedicine.medical_treatmentPrognosis.MedizinDECISION-MAKINGLogistic regressionlaw.inventionolder adult0302 clinical medicinePHYSICIANSInterquartile rangelaw80 and overMedicine and Health Sciences030212 general & internal medicineHospital MortalityProspective StudiesProspective cohort studyolder adultsAged 80 and overpredictddc:617Respiration[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontologyBrief ReportPrognosisIntensive care unitADMISSION3. Good healthEuropeHospitalizationIntensive Care UnitsBrier scoreOlder adultsArtificialFemaleprognosimedicine.medical_specialtycritical care; model; older adults; predict; prognosis; Aged 80 and over; Europe; Female; Hospital Mortality; Hospitalization; Humans; Intensive Care Units; Male; Prospective Studies; Respiration Artificial; Organ Dysfunction Scores; Prognosis03 medical and health sciencesIntensive caremedicineJournal ArticleHumansILL ELDERLY-PATIENTSRenal replacement therapyAgedmodelReceiver operating characteristicbusiness.industry030208 emergency & critical care medicineRespiration Artificialcritical careEmergency medicine[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieBrief ReportsprognosisGeriatrics and Gerontologybusiness
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Correction to: Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit (Intensive Care…

2018

In the original publication Dr Patrick Meybohm of the Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Frankfurt University Hospital, Frankfurt, Germany was inadvertently omitted from the list of investigators.

End of lifeICUwithdrawing
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Medical communications and writing for patients

2021

In this first edition of 2021’s Medical Writing, I am delighted to present a piece from Filippo Vitale and colleagues. This is a truly fascinating article that discusses how we have communicated science and scientific facts throughout history and how changes in societyhave affected how this is done and the outcomes that this has produced. I found this article extremely thought- provoking (and at times a sad reflection of where we have come to as a global society) as the authors document and explain concepts like “clickbait” and “fake news”. Whilst it was truly educational to understand the evolution of these concepts, I totally echo the authors’ call to arms in their plea for us to be more …

Medical communication
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Blood Component Therapy and Coagulopathy in Trauma: A Systematic Review of the Literature from the Trauma Update Group

2016

Background Traumatic coagulopathy is thought to increase mortality and its treatment to reduce preventable deaths. However, there is still uncertainty in this field, and available literature results may have been overestimated. Methods We searched the MEDLINE database using the PubMed platform. We formulated four queries investigating the prognostic weight of traumatic coagulopathy defined according to conventional laboratory testing, and the effectiveness in reducing mortality of three different treatments aimed at contrasting coagulopathy (high fresh frozen plasma/packed red blood cells ratios, fibrinogen, and tranexamic acid administration). Randomized controlled trials were selected alo…

Tranexamic acidPhysiologyGlycobiologylcsh:MedicineCardiovascular MedicinePathology and Laboratory MedicineBiochemistryVascular Medicinelaw.inventionDatabase and Informatics MethodsFresh frozen plasma0302 clinical medicineRandomized controlled trialCoagulopathyAnimal CellslawAntifibrinolytic agentFibrinogen; Fresh frozen plasma; Tranexamic acid; Antifibrinolytic agent.Medicine and Health Sciences030212 general & internal medicineDatabase Searchinglcsh:ScienceMultidisciplinaryPlasma ExchangeHematologyBlood Coagulation DisordersClinical Laboratory SciencesAntifibrinolytic AgentsBody FluidsBloodtraumaTranexamic AcidCardiovascular DiseasesResearch DesignMeta-analysisObservational StudiesFresh frozen plasmaAnatomyCellular TypesResearch ArticlePlateletsmedicine.medical_specialtyDeath RatesHemorrhageBlood Component TransfusionResearch and Analysis MethodsExternal validity03 medical and health sciencesSigns and SymptomsPopulation MetricsDiagnostic MedicinemedicineCoagulopathyHumansBlood TransfusionMortalityIntensive care medicineBlood CoagulationAntifibrinolytic Agents; Blood Coagulation Disorders; Humans; Mortality; Plasma Exchange; Tranexamic Acid; Wounds and Injuries; Blood Component Transfusion; Biochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)DemographyGlycoproteinsBlood CellsAntifibrinolytic agentPopulation BiologyCoagulation DisordersTransfusion Medicinebusiness.industrylcsh:RBleedingAntifibrinolytic agent.Biology and Life SciencesFibrinogen030208 emergency & critical care medicineCell Biologymedicine.diseaseSurgeryPeople and PlacesWounds and Injurieslcsh:QObservational studyPacked red blood cellsbusinessPLOS ONE
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Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials…

2019

Pardo-Oviedo, Juan Mauricio/0000-0003-0084-3449; Lopez-Delgado, Juan Carlos/0000-0003-3324-1129; Corradi, Francesco/0000-0002-5588-2608; De Backer, Daniel/0000-0001-9841-5762; POTA, VINCENZO/0000-0001-9999-3388; Tomescu, Dana/0000-0001-9673-5754; Sabetian, Golnar/0000-0001-8764-2150; Girardis, Massimo/0000-0002-2453-0829; Brazzi, Luca/0000-0001-7059-0622; Leone, Marc/0000-0002-3097-758X; Zabolotskikh, Igor Borisovich/0000-0002-3623-2546; De Lange, Dylan/0000-0002-0191-7270; ALMEKHLAFI, GHALEB A./0000-0002-0323-7025; Elke, Gunnar/0000-0002-4948-1605; Grigoras, Ioana/0000-0001-9412-9574; Czuczwar, Miroslaw/0000-0002-9025-6717; Nora, David/0000-0002-1133-7368; Masjedi, Mansoor/0000-0001-6175-9…

Infection riskMaleBIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences.Antibiotic resistanceTracte gastrointestinal - MalaltiesDefinitionsCritical Care and Intensive Care MedicineTHERAPYDEFINITIONS:Infections::Intraabdominal Infections [DISEASES]0302 clinical medicineIntensive care; Intra-abdominal infection; Mortality; Multidrug resistance; Peritonitis; Sepsis;[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesObservational studySeptic shockIntensive care; Intra-abdominal infection; Mortality; Multidrug resistance; Peritonitis; SepsisComputingMilieux_MISCELLANEOUSCritical Illness/epidemiology[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseasesBIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti.Intraabdominal Infections/epidemiologyAbdominal infectionMulticenter study3. Good healthManagementClinical trialCohort[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/VirologyCohort analysisCommunity acquired infectionCohort studyHumanmedicine.medical_specialtyCarbapenem resistanceCritical IllnessPeritoneal dialysisPeritonitisVancomycin resistant enterococcusMajor clinical studyPeritonitisArticle03 medical and health sciencesAntibiotic resistance[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemIntensive careSepsisSettore MED/41 - ANESTESIOLOGIAHumansCritical care medicineHospital infectionAgedScience & TechnologyLiver failureAntibiotic therapymedicine.disease[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyEpidemiologic Studies030228 respiratory systemIntensive Care Unit; Sepsis (Diptera); Septic ShockRisk factorHuman medicineGeneral & internal medicineCongestive heart failureOriginalMultidrug resistanceCohort StudiesRisk FactorsCause of DeathEpidemiologyPrevalenceMedicine and Health SciencesAbdominal abscessSepsis/epidemiologyMiddle agedAntifungal therapy2. Zero hungerPeritonitiAntibiotic agentBiliary tract infectionIntensive care ; Intra-abdominal infection ; Mortality ; Multidrug resistance ; Peritonitis ; SepsisMiddle Aged:infecciones bacterianas y micosis::infección::infecciones intraabdominales [ENFERMEDADES]PREVALENCE:Infections::Sepsis [DISEASES]:técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de cohortes [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]Methicillin resistant staphylococcus aureusRaonament basat en casosFemaleCritically ill patientLife Sciences & BiomedicineAntifungal agentAdult:Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cohort Studies [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]Predictive value:infecciones bacterianas y micosis::infección::sepsis [ENFERMEDADES]NOSepsisIntra-abdominal infectionCritical Care MedicineInternal medicineGeneral & Internal MedicinemedicineMANAGEMENTJournal Article[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/ParasitologySepticèmiaMortalitybusiness.industrySeptic shockPancreas diseaseMalnutrition030208 emergency & critical care medicineTyphlitisToxic megacolonIntensive careIntraabdominal InfectionsTherapyLate onset disorderbusiness
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Correction to: Procalcitonin levels in candidemia versus bacteremia: a systematic review (Critical care (London, England) (2019) 23 1 (190))

2019

The author wish to note there are three imprecisions in the article [1].

candidemiabacteremiaProcalcitonin
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Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: Post-hoc analysis of L…

2020

Abstract Background Limited information is available regarding intraoperative ventilator settings and the incidence of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgical procedures. The aim of this post-hoc analysis of the ‘Multicentre Local ASsessment of VEntilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) study was to examine the ventilator settings of patients undergoing neurosurgical procedures, and to explore the association between perioperative variables and the development of PPCs in neurosurgical patients. Methods Post-hoc analysis of LAS VEGAS study, restricted to patients undergoing neurosurgery. Patients were stratified into g…

Lung DiseasesMaleSURGERYmedicine.medical_treatment[SDV]Life Sciences [q-bio]RESPIRATORY-DISTRESS-SYNDROMEBRAIN-INJURYNeurosurgical ProceduresPositive-Pressure Respiration0302 clinical medicinePostoperative ComplicationsMechanical ventilation030202 anesthesiologyInterquartile rangeMedicine and Health SciencesGeneral anaesthesiaEND-EXPIRATORY-PRESSUREProspective StudiesPostoperative pulmonaryPostoperative pulmonary complicationsMiddle Aged3. Good health[SDV] Life Sciences [q-bio]AnesthesiaFemaleNeurosurgeryResearch ArticlePulmons MalaltiesAdultmedicine.medical_specialtycomplicationsNeurosurgeryLung injuryAnesthesia GeneralLAS VEGAS; Mechanical ventilation; Neurosurgery; Postoperative pulmonary complications;NOlcsh:RD78.3-87.3LAS VEGAS ; Mechanical ventilation ; Neurosurgery ; Postoperative pulmonary complications.03 medical and health sciencesNeurologiaLAS VEGASAnesthesiologymedicineTidal VolumeHumansMED/41 - ANESTESIOLOGIAHIGH TIDALAgedMechanical ventilationIntraoperative CareVentilators MechanicalCirurgiabusiness.industry030208 emergency & critical care medicineOdds ratioPerioperativeRespiration ArtificialAnesthesiology and Pain Medicinelcsh:AnesthesiologyVOLUMELAS VEGAS; Mechanical ventilation; Neurosurgery; Postoperative pulmonary complicationsbusinessPostoperative pulmonary complicationLUNG INJURY
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