6533b86cfe1ef96bd12c8073

RESEARCH PRODUCT

Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials Group Project

BlotS. Aemail AuthorAntonelli M. BC ArvanitiK. D BlotK. A Creagh-brownB. E FDe LangeD. GDe WaeleJ. H DeschepperM. I DikmenY. J DimopoulosG. K EckmannC. L FrancoisG. M GirardisM. N KoulentiD. O PLabeau S. AQ LipmanJ. R SLipovestky F. TMaseda E. UMontravers P. VW MikstackiA. X YPaivaJ. -A. ZPereyraC. AaRelloJ. AbTimsitJ. -F. AcAd VogelaersD. AeLamrous A.Rezende-neto J.Cardenas Y.Vymazal T.Fjeldsoee-nielsen H.Kott M.Kostoula A.Javeri Y.Einav S.Makikado L. D. U.Tomescu D.Gritsan A.Jovanovic B.Venkatesan K.Mirkovic T.Creagh-brown B.Lamrous A.Emmerich M.Canale M.Dietz L. S.Ilutovich S.Miñope J. T. S.Silva R. B.Montenegro M. A.Martin P.Saul P.Chediack V.Sutton G.Couce R.Balasini C.Gonzalez S.Lascar F. M.Descotte E. J.Gumiela N. S.Pino C. A.Cesio C.Valgolio E.Cunto E.Dominguez C.Nelson N. F.Abegao E. M.Pozo N. C.Bianchi L.Correger E.Pastorino M. L.Miyazaki E. A.Pozo N. C.Grubissich N.Garcia M.Bonetto N.Quevedo N. E.Gomez C. D.Queti F.Estevarena L. G.Fernandez R.Santolaya I.Pozo N. C.Grangeat S. H.Doglia J.Zakalik G.Pellegrini C.Lloria M. M.Chacon M. E.Fumale M.Leguizamon M.Hidalgo I. B.Tiranti R. J.Capponi P.Tita A.Cardonnet L.Bettini L.Ramos A.Lovesio L.Miranda E. M.Farfan A. B.Tolosa C.Segura L.Bellocchio A.Alvarez B.Manzur A.Lujan R.Fernandez N.Scarone N.Zazu A.Groh C.Fletcher J.Smith J.Azad R.Chavan N.Wong H.Kol M.Campbell L.Starr T.Roberts B.Wibrow B.Warhurst T.Chinthamuneedi M.Ferney B. B.Simon M.De BackerD. WitteboleDe BelsD. CollinV. DamsK. JorensP. DuboisJ. GunstJ. HaentjensDe SchryverN. DugernierT. Rezende-netoJ. RizoliS. SantillanP. HanY. BiskupE. QuC. LiX. YuT. WeihuaL. Molano-francoD. RojasJ. OviedoJ. M. P. PinillaD. CardenasY. CelisE. AriasM. VukovicA. VudragM. BelavicM. ZunicJ. KuharicJ. KrickaI. B. Filipovic-grcicI. TomasevicB. ObrazM. BodulicaB. DohnalM. MalaskaJ. KratochvilM. SatinskyI. SchwarzP. KosZ. BlahutL. MacaJ. ProtusM. KieslichováE. NielsenL. G. KroghB. M. RivadeneiraF. MoralesF. MoraJ. OrozcoA. S. MorochotutilloD. R. VargasN. R. YepezE. S. VillamaguaB. AlsisiA. FahmyA. DupontH. LasockiS. Paugam-burtzC. FoucrierA. NicaA. BarjonG. MallatJ. MarcotteG. LeoneM. DuclosG. BurtinP. AtchadeE. MahjoubY. MissetB. TimsitJ. -F.Dupuis C.Veber B.Debarre M.Collange O.Pottecher J.Hecketsweiler S.Fromentin M.Tesnière A.Koch C.Sander M.Kott M.Elke G.Wrigge H.Simon P.Chalkiadaki A.Tzanidakis C.Pneumatikos I.Sertaridou E.Mastora Z.Pantazopoulos I.Papanikolaou M.Papavasilopoulou T.Floros J.Kolonia V.Diakaki C.Rallis M.Paridou A.Kalogeromitros A.Romanou V.Nikolaou C.Kounougeri K.Tsigou E.Psallida V.Karampela N.Mandragos K.Kontoudaki E.Pentheroudaki A.Farazi-chongouki C.Karakosta A.Chouris I.Radu V.Malliotakis P.Kokkini S.Charalambous E.Kyritsi A.Koulouras V.Papathanakos G.Nagky E.Lampiri C.Tsimpoukas F.Sarakatsanos I.Georgakopoulos P.Ravani I.Prekates A.Sakellaridis K.Christopoulos C.Vrettou E.Stokkos K.Pentari A.Marmanidou K.Kydona C.Tsoumaropoulos G.Bitzani M.Kontou P.Voudouris A.Elli-nikki FlioniAntypa E.Chasou E.Anisoglou S.Papageorgiou E.Paraforou T.Tsioka A.Karathanou A.Vakalos A.Shah B.Thakkar C.Jain N.Gurjar M.Baronia A.Sathe P.Kulkarni S.Paul C.Paul J.Masjedi M.Nikandish R.Zand F.Sabetian G.Mahmoodpoor A.Hashemian S. M.Bala M.Flocco R.Torrente S.Pota V.Spadaro S.Volta C.Serafini G.Boraso S.Tiberio I.Cortegiani A.Misseri G.Barbagallo M.Nicolotti D.Forfori F.Corradi F.De PascaleG. PelagalliL. BrazziL. VittoneF. G. RussoA. SimionD. CotoiaA. CinnellaG. ToppinP. Johnson-jacksonR. HayashiY. YamamotoR. YasudaH. KishiharaY. ShiotsukaJ. Sanchez-hurtadoL. A. Tejeda-huezoB. GorordoL. ÑAmendys-silvaS. A. Garcia-guillenF. J. MartinezM. Romero-mejaE. Colorado-dominguezVan Den OeverH. KalffK. M. VermeijdenW. CornetA. D. BeckO. CimicN. DormansT. BormansL. BakkerVan DuijnD. BosmanG. VosP. HaasL. HeneinA. MirandaA. M. MakikadoL. D. U. MalcaG. E. G. Arroyo-sanchezA. Misiewska-kaczurA. AkinyiF. CzuczwarM. LuczakK. SulkowskiW. TamowiczB. SwitB. BaranowskiB. SmuszkiewiczP. TrojanowskaI. RzymskiS. SawinskiM. TrosiakM. Mikaszewska-sokolewiczM. AlvesR. LealD. KrystopchukA. MendoncaP. M. H. PereiraR. A.De CarvalhoM. R. L. M. CandeiasC. MolinosE. FerreiraA. CastroG. PereiraJ. -M.Santos L.Ferreira A.Pascoalinho D.Ribeiro R.Domingos G.Gomes P.Nora D.Costa R. P.Santos A.Alsheikhly A. S.Tomescu D.Popescu M.Grigoras I.Patrascanu E.Zabolotskikh I.Musaeva T.Gritsan A.Gaigolnik D.Kulabukhov V.Belskiy V.Zubareva N.Tribulev M.Abdelsalam A.Aldarsani A.Al-khalid M.Almekhlafi G.Mandourah Y.Jovanovic B.Doklestic K.Velickovic J.Velickovic D.Jankovic R.Vukovic A.Skoric-jokic S.Radovanovic D.Richards G.Alli A.Del Carmen Cordoba NielfaM. IniestaR. S. MartínezA. B. -C.Bernedo C. G.Gil S. A. P.Nuvials X.Garcia J. G.Peña J. M. G.Jimenez R.Herrera L.Barrachina L. G.Monzon I. C.Redondo F. J.Villazala R.Zapata D. F. M.Lopez I. M. V.Moreno-gonzalez G.Lopez-delgado J. C.Marin J. S.Sanchez-zamora P.Vidal M. V.González J. F.Salinas I.Hermosa C.Martinez-sagasti F.Domingo-marín S.Victorino J. A.Garcia-alvarez R.CallejaP. L. -A.De La Torre-pradosM. -V.Vidal-cortes P.Del Río-carbajoL. IzuraJ. MinguezV. AlvarezJ. T. ProusA. P. PazD. Roche-campoF. AguilarG. BeldaJ. Rico-feijooJ. AldecoaC. Zalba-etayoB. LangM. DullenkopfA. TrongtrakulK. ChtsomkasemA. AkbasT. UnalM. N. OzcelikM. GumusA. RamazanogluA. MemisD. MehmetI. UrkmezS. OzgultekinA. DemirkiranO. AslanN. A. KizilaslanD. KahveciF. ÜNlüN. OzkanZ. KayeC. JansenJ. O’neillO. NuttC. JhaR. HookerN. GrecuI. PetridouC. ShyamsundarM. McnameeL. TrinderJ. HaganS. KellyC. SilversidesJ. GrobaC. B. BoydO. BhowmickK. HumphreysS. SummersC. PolgarovaP. MargarsonM. DickensJ. PearsonS. ChineryE. HemmingsN. O’kaneS. AustinP. ColeS. PlowrightC. BoxR. WrightC. YoungL. MontagueL. ParkerR. MortonB. OstermannM. BilinskaJ. RoseB. O. Reece-anthonyR. RyanC. HamiltonM. HopkinsP. WendonJ. BresciaG. IjazN. WoodJ. GeorgeM. Toth-tarsolyP. YatesB. ArmstrongM. ScottC. BoydC. SzakmanyT. ReesD. PulakP. CoggonM. SahaB. KentL. GibsonB. CamsooksaiJ. ReschreiterH. MorganP. SangaralinghamS. LoweA. VondrasP. JamadarkhanaS. CruzC. BhandaryR. HerseyP. FurnevalJ. InnesR. DobleP. AttwoodB. ParsonsP. PageV. ZhaoX. GrecuI. DaltonJ. HegazyM. AwadY. NaylorD. NaylorA. LeeS. BrevardS. Davis

subject

Infection riskMaleBIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences.Antibiotic resistanceTracte gastrointestinal - MalaltiesDefinitionsCritical Care and Intensive Care MedicineTHERAPYDEFINITIONS:Infections::Intraabdominal Infections [DISEASES]0302 clinical medicineIntensive care; Intra-abdominal infection; Mortality; Multidrug resistance; Peritonitis; Sepsis;[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesObservational studySeptic shockIntensive care; Intra-abdominal infection; Mortality; Multidrug resistance; Peritonitis; SepsisComputingMilieux_MISCELLANEOUSCritical Illness/epidemiology[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseasesBIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti.Intraabdominal Infections/epidemiologyAbdominal infectionMulticenter study3. Good healthManagementClinical trialCohort[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/VirologyCohort analysisCommunity acquired infectionCohort studyHumanmedicine.medical_specialtyCarbapenem resistanceCritical IllnessPeritoneal dialysisPeritonitisVancomycin resistant enterococcusMajor clinical studyPeritonitisArticle03 medical and health sciencesAntibiotic resistance[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemIntensive careSepsisSettore MED/41 - ANESTESIOLOGIAHumansCritical care medicineHospital infectionAgedScience & TechnologyLiver failureAntibiotic therapymedicine.disease[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyEpidemiologic Studies030228 respiratory systemIntensive Care Unit; Sepsis (Diptera); Septic ShockRisk factorHuman medicineGeneral & internal medicineCongestive heart failureOriginalMultidrug resistanceCohort StudiesRisk FactorsCause of DeathEpidemiologyPrevalenceMedicine and Health SciencesAbdominal abscessSepsis/epidemiologyMiddle agedAntifungal therapy2. Zero hungerPeritonitiAntibiotic agentBiliary tract infectionIntensive care ; Intra-abdominal infection ; Mortality ; Multidrug resistance ; Peritonitis ; SepsisMiddle Aged:infecciones bacterianas y micosis::infección::infecciones intraabdominales [ENFERMEDADES]PREVALENCE:Infections::Sepsis [DISEASES]:técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de cohortes [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]Methicillin resistant staphylococcus aureusRaonament basat en casosFemaleCritically ill patientLife Sciences & BiomedicineAntifungal agentAdult:Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cohort Studies [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]Predictive value:infecciones bacterianas y micosis::infección::sepsis [ENFERMEDADES]NOSepsisIntra-abdominal infectionCritical Care MedicineInternal medicineGeneral & Internal MedicinemedicineMANAGEMENTJournal Article[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/ParasitologySepticèmiaMortalitybusiness.industrySeptic shockPancreas diseaseMalnutrition030208 emergency & critical care medicineTyphlitisToxic megacolonIntensive careIntraabdominal InfectionsTherapyLate onset disorderbusiness

description

Pardo-Oviedo, Juan Mauricio/0000-0003-0084-3449; Lopez-Delgado, Juan Carlos/0000-0003-3324-1129; Corradi, Francesco/0000-0002-5588-2608; De Backer, Daniel/0000-0001-9841-5762; POTA, VINCENZO/0000-0001-9999-3388; Tomescu, Dana/0000-0001-9673-5754; Sabetian, Golnar/0000-0001-8764-2150; Girardis, Massimo/0000-0002-2453-0829; Brazzi, Luca/0000-0001-7059-0622; Leone, Marc/0000-0002-3097-758X; Zabolotskikh, Igor Borisovich/0000-0002-3623-2546; De Lange, Dylan/0000-0002-0191-7270; ALMEKHLAFI, GHALEB A./0000-0002-0323-7025; Elke, Gunnar/0000-0002-4948-1605; Grigoras, Ioana/0000-0001-9412-9574; Czuczwar, Miroslaw/0000-0002-9025-6717; Nora, David/0000-0002-1133-7368; Masjedi, Mansoor/0000-0001-6175-9289; Gunst, Jan/0000-0003-2470-6393; Vidal-Cortes, Pablo/0000-0003-0225-9975; Szakmany, Tamas/0000-0003-3632-8844; Dimopoulos, George/0000-0002-3784-3103; Rello, Jordi/0000-0003-0676-6210; U nal, Necmettin/0000-0002-9440-7893; Tiberio, Iolanda FLC/0000-0002-5662-7895; Cortegiani, Andrea/0000-0003-1416-9993; Morton, Ben/0000-0002-6164-2854; Labeau, Sonia/0000-0003-3863-612X; Velickovic, Dejan/0000-0002-7312-2880; Paul, John/0000-0002-9307-3465; Pereira, Rui/0000-0002-3010-8384; Silversides, Jon/0000-0002-9562-5462; Paiva, Jose-Artur/0000-0003-4323-0220; Smuszkiewicz, Piotr/0000-0003-3067-8229; Paul, Cherish/0000-0001-6133-0036; Santos, Lurdes/0000-0002-0622-6823; PANTAZOPOULOS, IOANNIS/0000-0002-8846-519X; Ostermann, Marlies/0000-0001-9500-9080; Blot, Stijn/0000-0003-2145-0345; Naylor, Amanda/0000-0002-6431-0230; Shyamsundar, Murali/0000-0003-3797-8080; Aldecoa, Cesar/0000-0001-8789-5959; Summers, Charlotte/0000-0002-7269-2873; biskup, ewelina/0000-0002-9871-927X; Cornet, Alexander/0000-0002-9917-5251; Trenado Alvarez, Jose/0000-0002-2930-0766; Volta, Carlo/0000-0003-3533-6121; Gritsan, Alexey/0000-0002-0500-2887; Urkmez, Seval/0000-0002-3412-4226 WOS:000493268200001 PubMed ID: 31664501 PurposeTo describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock).MethodsWe performed a multicenter (n=309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis.ResultsThe cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation.ConclusionThis multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection. Pfizer investigator-initiated research grant AbSeS is a Trials Group Study of the European Society of Intensive Care Medicine. The study was supported by a Pfizer investigator-initiated research grant.

yearjournalcountryeditionlanguage
2019-12-01
10.1007/s00134-019-05819-3https://pure.qub.ac.uk/en/publications/9bd7d77d-58b9-4388-b73a-dc7ad5c0ec18