Zur Vaterschaftsplausibilität im HLA-System. Untersuchungen unter Benutzung verschiedener Haplotypfrequenztabellen

Serious discrepancies occur, when different haplotype frequency tables are used for calculating the “EM value” (\(\left( {\lg \frac{Y}{X} + 10} \right)\)) of a mother-child-putative-father-combination (MCPFC). These are due to the different frequencies of low frequent haplotypes. Since the correlation between the haplotype frequencies of two different tables for haplotypes lower than 3.5 X 10-3 may even be negative, it seems justified to calculate the EM values with the minimum haplotype frequency of 1X 10-3. For three haplotype frequency tables (with a respectively adapted number of antigens) the EM value was calculated for all MCPFC of all “full house” cases in which the genotype of fathe…