0000000000328810

AUTHOR

Salvatore Marasa

showing 3 related works from this author

Biologic Response of Inguinal Hernia Prosthetics: A Comparative Study of Conventional Static Meshes Versus 3D Dynamic Implants

2015

Despite improvements in prosthetics and surgi- cal techniques, the rate of complications following inguinal hernia repair remains high. Among these, discomfort and chronic pain have become a source of increasing concern among surgeons. Poor quality of tissue ingrowth, such as thin scar plates or shrinking scars—typical results with con- ventional static implants and plugs—may contribute to these adverse events. Recently, a new type of 3D dynami- cally responsive implant was introduced to the market. This device, designed to be placed fixation-free, seems to induce ingrowth of viable and structured tissue instead of regressive fibrotic scarring. To elucidate the differences in biologic respo…

medicine.medical_specialtyGroinbusiness.industryRegeneration (biology)Biomedical EngineeringMedicine (miscellaneous)Connective tissueBioengineeringGeneral Medicinemedicine.diseaseSurgeryBiomaterialsAbdominal wallInguinal herniamedicine.anatomical_structureMedicineImplantStatic meshbusinessProcess (anatomy)Artificial Organs
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Histological findings in direct inguinal hernia

2013

Abstract BACKGROUND: The study is focused on recognizing the histological changes of the structures close to and around the hernia opening in patients having direct inguinal hernia. METHODS: In 15 patients with primary bilateral direct inguinal hernia who underwent a Stoppa open posterior inguinal hernia repair, tissue specimens from the abdominal wall surrounding a direct hernia border were excised for histological examination. These findings in patients with direct inguinal hernia were compared with tissue specimens excised from the fossa inguinalis media of cadavers without hernia. RESULTS: Significant degenerative modifications such as fibrohyaline degeneration and fatty substitution of…

AdultMaleHyaline Muscular dystrophymedicine.medical_specialtyPathologyEtiologyFibrosiBiopsyHernia InguinalInflammationDirectAbdominal wallBiopsymedicineHumansHerniaNerve degenerationDirect Inguinal HerniaMuscle SkeletalInguinal hernia; Direct; Etiology; Inflammation; Muscles; Fibrosis; Hyaline Muscular dystrophy; Nerve degenerationHyalineAgedGroinmedicine.diagnostic_testbusiness.industryAbdominal WallInguinal herniaDystrophyMiddle Agedmedicine.diseaseFibrosisSurgerySettore MED/18 - Chirurgia Generalestomatognathic diseasesInguinal herniamedicine.anatomical_structureCase-Control StudiesMuscleSurgeryAtrophybusinessHernia
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IL-6 -174G/C polymorphism and IL-6 serum levels in patients with liver cirrhosis and hepatocellular carcinoma.

2011

Recently, a link between high levels of circulating IL-6 and hepatocellular carcinoma (HCC) has been proposed. In addition, single nucleotide polymorphisms (SNPs) in the promoter region of the IL-6 gene have been reported to be related to several inflammatory-related conditions, including cancer. The purpose of this article is: (1) to evaluate the frequencies of SNPs in the IL-6 promoter region at position -174 and IL-6 serum levels in a group of patients with HCC and underlying liver cirrhosis (LC), and compare them with a group of LC patients without HCC; (2) to determine whether a possible correlation exists between the allelic variations, IL-6 serum levels, and the risk of developing HC…

Liver CirrhosisMaleCirrhosisCarcinoma HepatocellularGenotypeSNPSingle-nucleotide polymorphismEnzyme-Linked Immunosorbent AssayBioinformaticsBiochemistryPolymerase Chain ReactionPolymorphism Single NucleotideGene FrequencyGeneticsmedicineHumansAlleleHCCInterleukin 6Molecular BiologyGeneIL-6biologyInterleukin-6Liver NeoplasmsPromotermedicine.diseaseHepatocellular carcinomabiology.proteinCancer researchIL-6 -174G/C polymorphism liver cirrhosis hepatocellular carcinomaMolecular MedicineFemaleRestriction fragment length polymorphismPolymorphism Restriction Fragment LengthBiotechnology
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