0000000000328959

AUTHOR

Kyle A. Furge

showing 2 related works from this author

UP-01.148 E2EPF as an Ubiquitin Carrier Protein Plays a Role in the Cancer Genesis of Papillary Renal Cell Carcinoma

2011

Pathologymedicine.medical_specialtyPapillary renal cell carcinomasUbiquitinbiologyCarrier proteinbusiness.industryUrologybiology.proteinmedicineCancermedicine.diseasebusinessUrology
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Deregulation of E2-EPF Ubiquitin Carrier Protein in Papillary Renal Cell Carcinoma

2011

Molecular pathways associated with pathogenesis of sporadic papillary renal cell carcinoma (PRCC), the second most common form of kidney cancer, are poorly understood. We analyzed primary tumor specimens from 35 PRCC patients treated by nephrectomy via gene expression analysis and tissue microarrays constructed from an additional 57 paraffin-embedded PRCC samples via immunohistochemistry. Gene products were validated and further studied by Western blot analyses using primary PRCC tumor samples and established renal cell carcinoma cell lines, and potential associations with pathologic variables and survival in 27 patients with follow-up information were determined. We show that the expressio…

MalePathologymedicine.medical_specialtyMolecular Sequence DataBiologyResponse ElementsPathology and Forensic MedicineRenal cell carcinomaGene expressionmedicineCarcinomaHumansCarcinoma Renal CellTissue microarrayBase SequencePapillary renal cell carcinomasRegular ArticleHypoxia-Inducible Factor 1 alpha SubunitPrognosismedicine.diseasePrimary tumorCell HypoxiaHEK293 CellsVon Hippel-Lindau Tumor Suppressor ProteinSporadic Papillary Renal Cell CarcinomaMutationUbiquitin-Conjugating EnzymesDisease ProgressionFemaleKidney cancerThe American Journal of Pathology
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