0000000000329164
AUTHOR
T. Yoshino
showing 2 related works from this author
Hypercube + Rubik’s Cube + Music = HyperCubeHarmonic
2022
Musical chords and chord relations can be described through mathematics. Abstract permutations can be visualized through the Rubik’s cube, born as a pedagogical device [7,21]. Permutations of notes can also be heard through the CubeHarmonic, a novel musical instru- ment. Here, we summarize the basic ideas and the state of the art of the physical implementation of CubeHarmonic, discussing its conceptual lift- ing up to the fourth dimension, with the HyperCubeHarmonic (HCH). We present the basics of the hypercube theory and of the 4-dimensional Rubik’s cube, investigating its potential for musical applications. To gain intuition about HCH complexity, we present two practical implementa- tions…
Association Between Tumor Egfr and Kras Mutation Status and Clinical Outcomes in Nsclc Patients Randomized to Sorafenib Plus Best Supportive Care (BS…
2012
ABSTRACT Background Tumor EGFR and KRas mutations are both predictive and prognostic biomarkers in patients with advanced NSCLC. We analyzed the correlation between these biomarkers and treatment outcomes in a phase III trial of 3rd/4th line sorafenib in patients with NSCLC. Methods The global, randomized, placebo-controlled MISSION trial enrolled 703 patients with advanced relapsed/refractory NSCLC of predominantly non-squamous histology. The primary study endpoint was overall survival (OS). EGFR and KRas mutations were analyzed in archival tumor samples and in circulating tumor DNA isolated from plasma. Results Tumor and/or plasma mutation data were available from 347 patients (49%). EGFR…