0000000000329408

AUTHOR

Anna Schneider

showing 3 related works from this author

Parentage Atlas of Italian Grapevine Varieties as Inferred From SNP Genotyping.

2021

The Italian grape germplasm is characterized by a high level of richness in terms of varieties number, with nearly 600 wine grape varieties listed in the Italian National Register of Grapevine Varieties and with a plethora of autochthonous grapes. In the present study an extended SNP genotyping has been carried out on Italian germplasm of cultivated Vitis vinifera subsp. sativa and Vitis hybrids. Several hundred Italian varieties maintained in the repositories of scientific Institutions and about one thousand additional varieties derived from previous studies on European, Southern Italy, Magna Graecia and Georgian germplasm were considered. The large genotyping data obtained were used to ch…

0106 biological sciences0301 basic medicineGermplasmPlant Sciencecultivar geographic areas; Italian founder varieties; Italian germplasm; parent-offspring relationships; pedigree; second-degree relationships; single nucleotide polymorphism; Vitis viniferalcsh:Plant culture01 natural sciencesWine grape03 medical and health sciencesPeninsulasingle nucleotide polymorphismlcsh:SB1-1110CultivarItalian founder varietiesVitis viniferaHybridOriginal Researchcultivar geographic areasgeography.geographical_feature_categorypedigreeVariety (linguistics)second-degree relationshipsGenealogySNP genotyping030104 developmental biologyGeographyItalian germplasmVitis viniferacultivar geographic areas Italian germplasm Italian founder varieties parent-offspring relationships pedigree second-degree relationships single nucleotide polymorphism Vitis viniferaparent-offspring relationships010606 plant biology & botanyFrontiers in plant science
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Insensitivity to Aβ42-lowering Nonsteroidal Anti-inflammatory Drugs and γ-Secretase Inhibitors Is Common among Aggressive Presenilin-1 Mutations

2007

Abeta42-lowering nonsteroidal anti-inflammatory drugs (NSAIDs) constitute the founding members of a new class of gamma-secretase modulators that avoid side effects of pan-gamma-secretase inhibitors on NOTCH processing and function, holding promise as potential disease-modifying agents for Alzheimer disease (AD). These modulators are active in cell-free gamma-secretase assays indicating that they directly target the gamma-secretase complex. Additional support for this hypothesis was provided by the observation that certain mutations in presenilin-1 (PS1) associated with early-onset familial AD (FAD) change the cellular drug response to Abeta42-lowering NSAIDs. Of particular interest is the P…

TransgeneMolecular Sequence DataMutantMice TransgenicCHO CellsBiologyPharmacologymedicine.disease_causeBiochemistryPresenilinMiceExonCricetulusAlzheimer DiseaseIn vivoCricetinaePresenilin-1medicineAnimalsHumansAmino Acid SequenceEnzyme InhibitorsMolecular BiologyMutationAmyloid beta-PeptidesSequence Homology Amino AcidDrug discoveryAnti-Inflammatory Agents Non-SteroidalCell BiologyPeptide FragmentsMutationbiology.proteinAmyloid Precursor Protein SecretasesAmyloid precursor protein secretaseJournal of Biological Chemistry
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O1–02–06: Genetic dissection of the PS1–ΔExon9 mutation and its attenuated response to Aβ42–lowering NSAIDs

2006

Psychiatry and Mental healthCellular and Molecular NeuroscienceDevelopmental NeuroscienceEpidemiologyHealth PolicyNeurology (clinical)Geriatrics and GerontologyAlzheimer's & Dementia
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